Wiley Interdiscip Rev Syst Biol Med - Modeling the intracellular organization of calcium signaling.

Tópicos

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Resumo

Calcium (Ca?) is a key signaling ion that plays a fundamental role in many cellular processes in most types of tissues and organisms. The versatility of this signaling pathway is remarkable. Depending on the cell type and the stimulus, intracellular Ca? increases can last over different periods, as short spikes or more sustained signals. From a spatial point of view, they can be localized or invade the whole cell. Such a richness of behaviors is possible thanks to numerous exchange processes with the external medium or internal Ca? pools, mainly the endoplasmic or sarcoplasmic reticulum and mitochondria. These fluxes are also highly regulated. In order to get an accurate description of the spatiotemporal organization of Ca? signaling, it is useful to resort to modeling. Thus, each flux can be described by an appropriate kinetic expression. Ca? dynamics in a given cell type can then be simulated by a modular approach, consisting of the assembly of computational descriptions of the appropriate fluxes and regulations. Modeling can also be used to get insight into the mechanisms of decoding of the Ca? signals responsible for cellular responses. Cells can use frequency or amplitude coding, as well as take profit of Ca? oscillations to increase their sensitivity to small average Ca? increases.

Resumo Limpo

calcium ca key signal ion play fundament role mani cellular process type tissu organ versatil signal pathway remark depend cell type stimulus intracellular ca increas can last differ period short spike sustain signal spatial point view can local invad whole cell rich behavior possibl thank numer exchang process extern medium intern ca pool main endoplasm sarcoplasm reticulum mitochondria flux also high regul order get accur descript spatiotempor organ ca signal use resort model thus flux can describ appropri kinet express ca dynam given cell type can simul modular approach consist assembl comput descript appropri flux regul model can also use get insight mechan decod ca signal respons cellular respons cell can use frequenc amplitud code well take profit ca oscil increas sensit small averag ca increas

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