Wiley Interdiscip Rev Syst Biol Med - Glass-like dynamics in the cell and in cellular collectives.

Tópicos

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{ model(2220) cell(1177) simul(1124) }
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{ data(3963) clinic(1234) research(1004) }
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{ drug(1928) target(777) effect(648) }
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{ featur(1941) imag(1645) propos(1176) }
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{ perform(1367) use(1326) method(1137) }
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{ record(1888) medic(1808) patient(1693) }
{ health(3367) inform(1360) care(1135) }
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{ ehr(2073) health(1662) electron(1139) }
{ research(1218) medic(880) student(794) }
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{ model(2656) set(1616) predict(1553) }
{ age(1611) year(1155) adult(843) }
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{ cost(1906) reduc(1198) effect(832) }
{ group(2977) signific(1463) compar(1072) }
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{ health(1844) social(1437) communiti(874) }
{ cancer(2502) breast(956) screen(824) }
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{ survey(1388) particip(1329) question(1065) }
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{ activ(1452) weight(1219) physic(1104) }
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{ method(2212) result(1239) propos(1039) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

Prominent fluctuations, heterogeneity, and cooperativity dominate the dynamics of the cytoskeleton as well as the dynamics of the cellular collective. Such systems are out of equilibrium, disordered, and remain poorly understood. To explain these findings, we consider a unifying mechanistic rubric that imagines these systems as comprising phases of soft condensed matter in proximity to a glass or jamming transition, with associated transitions between solid-like versus liquid-like phases. At the scale of the cytoskeleton, data suggest that intermittent dynamics, kinetic arrest, and dynamic heterogeneity represent mesoscale features of glassy protein-protein interactions that link underlying biochemical events to integrative cellular behaviors such as crawling, contraction, and remodeling. At the scale of the multicellular collective, jamming has the potential to unify diverse biological factors that previously had been considered mostly as acting separately and independently. Although a quantitative relationship between intra- and intercellular dynamics is still lacking, glassy dynamics and jamming offer insights linking the mechanobiology of cell to human physiology and pathophysiology.

Resumo Limpo

promin fluctuat heterogen cooper domin dynam cytoskeleton well dynam cellular collect system equilibrium disord remain poor understood explain find consid unifi mechanist rubric imagin system compris phase soft condens matter proxim glass jam transit associ transit solidlik versus liquidlik phase scale cytoskeleton data suggest intermitt dynam kinet arrest dynam heterogen repres mesoscal featur glassi proteinprotein interact link under biochem event integr cellular behavior crawl contract remodel scale multicellular collect jam potenti unifi divers biolog factor previous consid most act separ independ although quantit relationship intra intercellular dynam still lack glassi dynam jam offer insight link mechanobiolog cell human physiolog pathophysiolog

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