Wiley Interdiscip Rev Syst Biol Med - Cyclic nucleotide signaling in intestinal epithelia: getting to the gut of the matter.

Tópicos

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Resumo

The intestine is the primary site of nutrient absorption, fluid-ion secretion, and home to trillions of symbiotic microbiota. The high turnover of the intestinal epithelia also renders it susceptible to neoplastic growth. These diverse processes are carefully regulated by an intricate signaling network. Among the myriad molecules involved in intestinal epithelial cell homeostasis are the second messengers, cyclic AMP (cAMP) and cyclic GMP (cGMP). These cyclic nucleotides are synthesized by nucleotidyl cyclases whose activities are regulated by extrinsic and intrinsic cues. Downstream effectors of cAMP and cGMP include protein kinases, cyclic nucleotide gated ion channels, and transcription factors, which modulate key processes such as ion-balance, immune response, and cell proliferation. The web of interaction involving the major signaling pathways of cAMP and cGMP in the intestinal epithelial cell, and possible cross-talk among the pathways, are highlighted in this review. Deregulation of these pathways occurs during infection by pathogens, intestinal inflammation, and cancer. Thus, an appreciation of the importance of cyclic nucleotide signaling in the intestine furthers our understanding of bowel disease, thereby aiding in the development of therapeutic approaches.

Resumo Limpo

intestin primari site nutrient absorpt fluidion secret home trillion symbiot microbiota high turnov intestin epithelia also render suscept neoplast growth divers process care regul intric signal network among myriad molecul involv intestin epitheli cell homeostasi second messeng cyclic amp camp cyclic gmp cgmp cyclic nucleotid synthes nucleotidyl cyclas whose activ regul extrins intrins cue downstream effector camp cgmp includ protein kinas cyclic nucleotid gate ion channel transcript factor modul key process ionbal immun respons cell prolifer web interact involv major signal pathway camp cgmp intestin epitheli cell possibl crosstalk among pathway highlight review deregul pathway occur infect pathogen intestin inflamm cancer thus appreci import cyclic nucleotid signal intestin further understand bowel diseas therebi aid develop therapeut approach

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