Wiley Interdiscip Rev Syst Biol Med - Toward a quantitative understanding of the Wnt/?-catenin pathway through simulation and experiment.

Tópicos

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Resumo

Wnt signaling regulates cell survival, proliferation, and differentiation throughout development and is aberrantly regulated in cancer. The pathway is activated when Wnt ligands bind to specific receptors on the cell surface, resulting in the stabilization and nuclear accumulation of the transcriptional co-activator ?-catenin. Mathematical and computational models have been used to study the spatial and temporal regulation of the Wnt/?-catenin pathway and to investigate the functional impact of mutations in key components. Such models range in complexity, from time-dependent, ordinary differential equations that describe the biochemical interactions between key pathway components within a single cell, to complex, multiscale models that incorporate the role of the Wnt/?-catenin pathway target genes in tissue homeostasis and carcinogenesis. This review aims to summarize recent progress in mathematical modeling of the Wnt pathway and to highlight new biological results that could form the basis for future theoretical investigations designed to increase the utility of theoretical models of Wnt signaling in the biomedical arena.

Resumo Limpo

wnt signal regul cell surviv prolifer differenti throughout develop aberr regul cancer pathway activ wnt ligand bind specif receptor cell surfac result stabil nuclear accumul transcript coactiv catenin mathemat comput model use studi spatial tempor regul wntcatenin pathway investig function impact mutat key compon model rang complex timedepend ordinari differenti equat describ biochem interact key pathway compon within singl cell complex multiscal model incorpor role wntcatenin pathway target gene tissu homeostasi carcinogenesi review aim summar recent progress mathemat model wnt pathway highlight new biolog result form basi futur theoret investig design increas util theoret model wnt signal biomed arena

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