Wiley Interdiscip Rev Syst Biol Med - A systems biology approach to synovial joint lubrication in health, injury, and disease.

Tópicos

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Resumo

The synovial joint contains synovial fluid (SF) within a cavity bounded by articular cartilage and synovium. SF is a viscous fluid that has lubrication, metabolic, and regulatory functions within synovial joints. SF contains lubricant molecules, including proteoglycan-4 and hyaluronan. SF is an ultrafiltrate of plasma with secreted contributions from cell populations lining and within the synovial joint space, including chondrocytes and synoviocytes. Maintenance of normal SF lubricant composition and function are important for joint homeostasis. In osteoarthritis, rheumatoid arthritis, and joint injury, changes in lubricant composition and function accompany alterations in the cytokine and growth factor environment and increased fluid and molecular transport through joint tissues. Thus, understanding the synovial joint lubrication system requires a multifaceted study of the various parts of the synovial joint and their interactions. Systems biology approaches at multiple scales are being used to describe the molecular, cellular, and tissue components and their interactions that comprise the functioning synovial joint. Analyses of the transcriptome and proteome of SF, cartilage, and synovium suggest that particular molecules and pathways play important roles in joint homeostasis and disease. Such information may be integrated with physicochemical tissue descriptions to construct integrative models of the synovial joint that ultimately may explain maintenance of health, recovery from injury, or development and progression of arthritis.

Resumo Limpo

synovi joint contain synovi fluid sf within caviti bound articular cartilag synovium sf viscous fluid lubric metabol regulatori function within synovi joint sf contain lubric molecul includ proteoglycan hyaluronan sf ultrafiltr plasma secret contribut cell popul line within synovi joint space includ chondrocyt synoviocyt mainten normal sf lubric composit function import joint homeostasi osteoarthr rheumatoid arthriti joint injuri chang lubric composit function accompani alter cytokin growth factor environ increas fluid molecular transport joint tissu thus understand synovi joint lubric system requir multifacet studi various part synovi joint interact system biolog approach multipl scale use describ molecular cellular tissu compon interact compris function synovi joint analys transcriptom proteom sf cartilag synovium suggest particular molecul pathway play import role joint homeostasi diseas inform may integr physicochem tissu descript construct integr model synovi joint ultim may explain mainten health recoveri injuri develop progress arthriti

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