Wiley Interdiscip Rev Syst Biol Med - Where gene discovery turns into systems biology: genome-scale RNAi screens in Drosophila.

Tópicos

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Resumo

Systems biology aims to describe the complex interplays between cellular building blocks which, in their concurrence, give rise to the emergent properties observed in cellular behaviors and responses. This approach tries to determine the molecular players and the architectural principles of their interactions within the genetic networks that control certain biological processes. Large-scale loss-of-function screens, applicable in various different model systems, have begun to systematically interrogate entire genomes to identify the genes that contribute to a certain cellular response. In particular, RNA interference (RNAi)-based high-throughput screens have been instrumental in determining the composition of regulatory systems and paired with integrative data analyses have begun to delineate the genetic networks that control cell biological and developmental processes. Through the creation of tools for both, in vitro and in vivo genome-wide RNAi screens, Drosophila melanogaster has emerged as one of the key model organisms in systems biology research and over the last years has massively contributed to and hence shaped this discipline. WIREs Syst Biol Med 2011 3 471-478 DOI: 10.1002/wsbm.127

Resumo Limpo

system biolog aim describ complex interplay cellular build block concurr give rise emerg properti observ cellular behavior respons approach tri determin molecular player architectur principl interact within genet network control certain biolog process largescal lossoffunct screen applic various differ model system begun systemat interrog entir genom identifi gene contribut certain cellular respons particular rna interfer rnaibas highthroughput screen instrument determin composit regulatori system pair integr data analys begun delin genet network control cell biolog development process creation tool vitro vivo genomewid rnai screen drosophila melanogast emerg one key model organ system biolog research last year massiv contribut henc shape disciplin wire syst biol med doi wsbm

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