Wiley Interdiscip Rev Syst Biol Med - The zebrafish: scalable in vivo modeling for systems biology.

Tópicos

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Resumo

The zebrafish offers a scalable vertebrate model for many areas of biologic investigation. There is substantial conservation of genetic and genomic features and, at a higher order, conservation of intermolecular networks, as well as physiologic systems and phenotypes. We highlight recent work demonstrating the extent of this homology, and efforts to develop high-throughput phenotyping strategies suited to genetic or chemical screening on a scale compatible with in vivo validation for systems biology. We discuss the implications of these approaches for functional annotation of the genome, elucidation of multicellular processes in vivo, and mechanistic exploration of hypotheses generated by a broad range of 'unbiased' 'omic technologies such as expression profiling and genome-wide association. Finally, we outline potential strategies for the application of the zebrafish to the systematic study of phenotypic architecture, disease heterogeneity and drug responses.

Resumo Limpo

zebrafish offer scalabl vertebr model mani area biolog investig substanti conserv genet genom featur higher order conserv intermolecular network well physiolog system phenotyp highlight recent work demonstr extent homolog effort develop highthroughput phenotyp strategi suit genet chemic screen scale compat vivo valid system biolog discuss implic approach function annot genom elucid multicellular process vivo mechanist explor hypothes generat broad rang unbias omic technolog express profil genomewid associ final outlin potenti strategi applic zebrafish systemat studi phenotyp architectur diseas heterogen drug respons

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