Wiley Interdiscip Rev Syst Biol Med - Signaling networks in palate development.

Tópicos

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Resumo

LABELLED: Palatogenesis, the formation of the palate, is a dynamic process regulated by a complex series of context-dependent morphogenetic signaling events. Many genes involved in palatogenesis have been discovered through the use of genetically manipulated mouse models as well as from human genetic studies, but the roles of these genes and their products in signaling networks regulating palatogenesis are still poorly known. In this review, we give a brief overview on palatogenesis and introduce key signaling cascades leading to formation of the intact palate. Moreover, we review conceptual differences between pathway biology and network biology and discuss how some of the recent technological advances in conjunction with mouse genetic models have contributed to our understanding of signaling networks regulating palate growth and fusion. For further resources related to this article, please visit the WIREs website.CONFLICT OF INTEREST: The authors have declared no conflicts of interest for this article.

Resumo Limpo

label palatogenesi format palat dynam process regul complex seri contextdepend morphogenet signal event mani gene involv palatogenesi discov use genet manipul mous model well human genet studi role gene product signal network regul palatogenesi still poor known review give brief overview palatogenesi introduc key signal cascad lead format intact palat moreov review conceptu differ pathway biolog network biolog discuss recent technolog advanc conjunct mous genet model contribut understand signal network regul palat growth fusion resourc relat articl pleas visit wire websiteconflict interest author declar conflict interest articl

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