Wiley Interdiscip Rev Syst Biol Med - Riding the crest of the wave: parallels between the neural crest and cancer in epithelial-to-mesenchymal transition and migration.

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Resumo

The neural crest (NC) is first induced as an epithelial population of cells at the neural plate border requiring complex signaling between bone morphogenetic protein, Wnt, and fibroblast growth factors to differentiate the neural and NC fate from the epidermis. Remarkably, following induction, these cells undergo an epithelial-to-mesenchymal transition (EMT), delaminate from the neural tube, and migrate through various tissue types and microenvironments before reaching their final destination where they undergo terminal differentiation. This process is mirrored in cancer metastasis, where a primary tumor will undergo an EMT before migrating and invading other cell populations to create a secondary tumor site. In recent years, as our understanding of NC EMT and migration has deepened, important new insights into tumorigenesis and metastasis have also been achieved. These discoveries have been driven by the observation that many cancers misregulate developmental genes to reacquire proliferative and migratory states. In this review, we examine how the NC provides an excellent model for studying EMT and migration. These data are discussed from the perspective of the gene regulatory networks that control both NC and cancer cell EMT and migration. Deciphering these processes in a comparative manner will expand our knowledge of the underlying etiology and pathogenesis of cancer and promote the development of novel targeted therapeutic strategies for cancer patients.

Resumo Limpo

neural crest nc first induc epitheli popul cell neural plate border requir complex signal bone morphogenet protein wnt fibroblast growth factor differenti neural nc fate epidermi remark follow induct cell undergo epithelialtomesenchym transit emt delamin neural tube migrat various tissu type microenviron reach final destin undergo termin differenti process mirror cancer metastasi primari tumor will undergo emt migrat invad cell popul creat secondari tumor site recent year understand nc emt migrat deepen import new insight tumorigenesi metastasi also achiev discoveri driven observ mani cancer misregul development gene reacquir prolif migratori state review examin nc provid excel model studi emt migrat data discuss perspect gene regulatori network control nc cancer cell emt migrat deciph process compar manner will expand knowledg under etiolog pathogenesi cancer promot develop novel target therapeut strategi cancer patient

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