Wiley Interdiscip Rev Syst Biol Med - Systems biology approaches to finding novel pain mediators.

Tópicos

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Resumo

Chronic pain represents a major health burden; this maladaptive pain state occurs as a consequence of hypersensitivity within the peripheral and central components of the somatosensory system. High throughput technologies (genomics, transciptomics, lipidomics, and proteomics) are now being applied to tissue derived from pain patients as well as experimental pain models to discover novel pain mediators. The use of clustering, meta-analysis and other techniques can help refine potential candidates. Of particular importance are systems biology methods, such as co-expression network generating algorithms, which infer potential associations/interactions between molecules and build networks based on these interactions. Protein-protein interaction networks allow the lists of potential targets generated by these different platforms to be analyzed in their biological context. Outputs from these different methods must also be related to the clinical pain phenotype. The improved and standardized phenotyping of pain symptoms and sensory signs enables much better subject stratification. Our hope is that, in the future, the use of computational approaches to integrate datasets including sensory phenotype as well as the outputs of high throughput technologies will help define novel pain mediators and provide insights into the pathogenesis of chronic pain.

Resumo Limpo

chronic pain repres major health burden maladapt pain state occur consequ hypersensit within peripher central compon somatosensori system high throughput technolog genom transciptom lipidom proteom now appli tissu deriv pain patient well experiment pain model discov novel pain mediat use cluster metaanalysi techniqu can help refin potenti candid particular import system biolog method coexpress network generat algorithm infer potenti associationsinteract molecul build network base interact proteinprotein interact network allow list potenti target generat differ platform analyz biolog context output differ method must also relat clinic pain phenotyp improv standard phenotyp pain symptom sensori sign enabl much better subject stratif hope futur use comput approach integr dataset includ sensori phenotyp well output high throughput technolog will help defin novel pain mediat provid insight pathogenesi chronic pain

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