Wiley Interdiscip Rev Syst Biol Med - Large-scale mouse knockouts and phenotypes.

Tópicos

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Resumo

Standardized phenotypic analysis of mutant forms of every gene in the mouse genome will provide fundamental insights into mammalian gene function and advance human and animal health. The availability of the human and mouse genome sequences, the development of embryonic stem cell mutagenesis technology, the standardization of phenotypic analysis pipelines, and the paradigm-shifting industrialization of these processes have made this a realistic and achievable goal. The size of this enterprise will require global coordination to ensure economies of scale in both the generation and primary phenotypic analysis of the mutant strains, and to minimize unnecessary duplication of effort. To provide more depth to the functional annotation of the genome, effective mechanisms will also need to be developed to disseminate the information and resources produced to the wider community. Better models of disease, potential new drug targets with novel mechanisms of action, and completely unsuspected genotype-phenotype relationships covering broad aspects of biology will become apparent. To reach these goals, solutions to challenges in mouse production and distribution, as well as development of novel, ever more powerful phenotypic analysis modalities will be necessary. It is a challenging and exciting time to work in mouse genetics.

Resumo Limpo

standard phenotyp analysi mutant form everi gene mous genom will provid fundament insight mammalian gene function advanc human anim health avail human mous genom sequenc develop embryon stem cell mutagenesi technolog standard phenotyp analysi pipelin paradigmshift industri process made realist achiev goal size enterpris will requir global coordin ensur economi scale generat primari phenotyp analysi mutant strain minim unnecessari duplic effort provid depth function annot genom effect mechan will also need develop dissemin inform resourc produc wider communiti better model diseas potenti new drug target novel mechan action complet unsuspect genotypephenotyp relationship cover broad aspect biolog will becom appar reach goal solut challeng mous product distribut well develop novel ever power phenotyp analysi modal will necessari challeng excit time work mous genet

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