Wiley Interdiscip Rev Syst Biol Med - The molecular circuitry underlying pluripotency in embryonic stem cells.

Tópicos

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Resumo

Cells in the pluripotent state have the ability to self-renew indefinitely and to differentiate to all the cells of the embryo. These cells provide an in vitro window into development, including human development, as well as holding extraordinary promise for cell-based therapies in regenerative medicine. The recent demonstration that somatic cells can be reprogrammed to the pluripotent state has raised the possibility of patient and disease-specific induced pluripotent cells. In this article, we review the molecular underpinning of pluripotency. We focus on the transcriptional and signaling networks that underlie the state of pluripotency and control differentiation. In general, the action of each of the molecular components and pathways is dose and context dependent highlighting the need for a systems approach to understanding pluripotency.

Resumo Limpo

cell pluripot state abil selfrenew indefinit differenti cell embryo cell provid vitro window develop includ human develop well hold extraordinari promis cellbas therapi regen medicin recent demonstr somat cell can reprogram pluripot state rais possibl patient diseasespecif induc pluripot cell articl review molecular underpin pluripot focus transcript signal network underli state pluripot control differenti general action molecular compon pathway dose context depend highlight need system approach understand pluripot

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