Wiley Interdiscip Rev Syst Biol Med - Diverse functional networks of Tbx3 in development and disease.

Tópicos

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Resumo

The T-box transcription factor Tbx3 plays multiple roles in normal development and disease. In order to function in different tissues and on different target genes, Tbx3 binds transcription factors or other cofactors specific to temporal or spatial locations. Examining the development of the mammary gland, limbs, and heart as well as the biology of stem cells and cancer provides insights into the diverse and common functions that Tbx3 can perform. By either repressing or activating transcription of target genes in a context-dependent manner, Tbx3 is able to modulate differentiation of immature progenitor cells, control the rate of cell proliferation, and mediate cellular signaling pathways. Because the direct regulators of these cellular processes are highly context-dependent, it is essential that Tbx3 has the flexibility to regulate transcription of a large group of targets, but only become a active on a small cohort of them at any given time or place. Moreover, Tbx3 must be responsive to the variety of different upstream factors that are present in different tissues. Only by understanding the network of genes, proteins, and molecules with which Tbx3 interacts can we hope to understand the role that Tbx3 plays in normal development and how its aberrant expression can lead to disease. Because of its myriad functions in disparate developmental and disease contexts, Tbx3 is an ideal candidate for a systems-based approach to genetic function and interaction.

Resumo Limpo

tbox transcript factor tbx play multipl role normal develop diseas order function differ tissu differ target gene tbx bind transcript factor cofactor specif tempor spatial locat examin develop mammari gland limb heart well biolog stem cell cancer provid insight divers common function tbx can perform either repress activ transcript target gene contextdepend manner tbx abl modul differenti immatur progenitor cell control rate cell prolifer mediat cellular signal pathway direct regul cellular process high contextdepend essenti tbx flexibl regul transcript larg group target becom activ small cohort given time place moreov tbx must respons varieti differ upstream factor present differ tissu understand network gene protein molecul tbx interact can hope understand role tbx play normal develop aberr express can lead diseas myriad function dispar development diseas context tbx ideal candid systemsbas approach genet function interact

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