Wiley Interdiscip Rev Syst Biol Med - Engineered tissue grafts: opportunities and challenges in regenerative medicine.

Tópicos

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Resumo

The human body has limited regenerative capacity in most of the major tissues and organs. This fact has spurred the field of regenerative medicine, promising to repair damage following traumatic injury or disease. Multiple therapeutic strategies are being explored including small molecules, gene delivery, and stem cells; however, tissue engineering remains a primary approach to achieving regeneration. Organ transplantation demonstrates that damaged tissues can be replaced, but technology to regenerate complex organs de novo is not yet available. Instead, tissue engineering can augment the body's own regenerative ability by replacing tissue sections and enhancing the regenerative cascade. As a consequence of these opportunities, it is timely to review the criteria and current status of engineered tissue grafts designed as patches to replace or regenerate damaged or diseased tissue and restore organ function. This topic will be explored starting from the biomaterials and cells incorporated into the engineered graft, the environment into which the graft is implanted and the integration of the engineered graft with the host. Common issues will be addressed that are relevant to regeneration in multiple tissue and organ systems. Specific examples will focus on engineered grafts for myocardial and corneal repair to illustrate the tissue-specific challenges and opportunities and highlight the innovation needed as the field moves forward.

Resumo Limpo

human bodi limit regen capac major tissu organ fact spur field regen medicin promis repair damag follow traumat injuri diseas multipl therapeut strategi explor includ small molecul gene deliveri stem cell howev tissu engin remain primari approach achiev regener organ transplant demonstr damag tissu can replac technolog regener complex organ de novo yet avail instead tissu engin can augment bodi regen abil replac tissu section enhanc regen cascad consequ opportun time review criteria current status engin tissu graft design patch replac regener damag diseas tissu restor organ function topic will explor start biomateri cell incorpor engin graft environ graft implant integr engin graft host common issu will address relev regener multipl tissu organ system specif exampl will focus engin graft myocardi corneal repair illustr tissuespecif challeng opportun highlight innov need field move forward

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