Wiley Interdiscip Rev Syst Biol Med - Mathematical modeling of kidney transport.

Tópicos

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Resumo

In addition to metabolic waste and toxin excretion, the kidney also plays an indispensable role in regulating the balance of water, electrolytes, nitrogen, and acid-base. In this review, we describe representative mathematical models that have been developed to better understand kidney physiology and pathophysiology, including the regulation of glomerular filtration, the regulation of renal blood flow by means of the tubuloglomerular feedback mechanisms and of the myogenic mechanism, the urine concentrating mechanism, epithelial transport, and regulation of renal oxygen transport. We discuss the extent to which these modeling efforts have expanded our understanding of renal function in both health and disease.

Resumo Limpo

addit metabol wast toxin excret kidney also play indispens role regul balanc water electrolyt nitrogen acidbas review describ repres mathemat model develop better understand kidney physiolog pathophysiolog includ regul glomerular filtrat regul renal blood flow mean tubuloglomerular feedback mechan myogen mechan urin concentr mechan epitheli transport regul renal oxygen transport discuss extent model effort expand understand renal function health diseas

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