Wiley Interdiscip Rev Syst Biol Med - Toward the virtual stomach: progress in multiscale modeling of gastric electrophysiology and motility.

Tópicos

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Resumo

Experimental progress in investigating normal and disordered gastric motility is increasingly being complimented by sophisticated multiscale modeling studies. Mathematical modeling has become a valuable tool in this effort, as there is an ever-increasing need to gain an integrative and quantitative understanding of how physiological mechanisms achieve coordinated functions across multiple biophysical scales. These interdisciplinary efforts have been particularly notable in the area of gastric electrophysiology, where they are beginning to yield a comprehensive and integrated in silico organ modeling framework, or 'virtual stomach'. At the cellular level, a number of biophysically based mathematical cell models have been developed, and these are now being applied in areas including investigations of gastric electrical pacemaker mechanisms, smooth muscle electrophysiology, and electromechanical coupling. At the tissue level, micro-structural models are being creatively developed and employed to investigate clinically significant questions, such as the functional effects of ICC degradation on gastrointestinal (GI) electrical activation. At the organ level, high-resolution electrical mapping and modeling studies are combined to provide improved insights into normal and dysrhythmic gastric electrical activation. These efforts are also enabling detailed forward and inverse modeling studies at the 'whole body' level, with implications for diagnostic techniques for gastric dysrhythmias. These recent advances, together with several others highlighted in this review, collectively demonstrate a powerful trend toward applying mathematical models to effectively investigate structure-function relationships and overcome multiscale challenges in basic and clinical GI research.

Resumo Limpo

experiment progress investig normal disord gastric motil increas compliment sophist multiscal model studi mathemat model becom valuabl tool effort everincreas need gain integr quantit understand physiolog mechan achiev coordin function across multipl biophys scale interdisciplinari effort particular notabl area gastric electrophysiolog begin yield comprehens integr silico organ model framework virtual stomach cellular level number biophys base mathemat cell model develop now appli area includ investig gastric electr pacemak mechan smooth muscl electrophysiolog electromechan coupl tissu level microstructur model creativ develop employ investig clinic signific question function effect icc degrad gastrointestin gi electr activ organ level highresolut electr map model studi combin provid improv insight normal dysrhythm gastric electr activ effort also enabl detail forward invers model studi whole bodi level implic diagnost techniqu gastric dysrhythmia recent advanc togeth sever other highlight review collect demonstr power trend toward appli mathemat model effect investig structurefunct relationship overcom multiscal challeng basic clinic gi research

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