Wiley Interdiscip Rev Syst Biol Med - Hierarchical approaches for systems modeling in cardiac development.

Tópicos

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Resumo

Ordered cardiac morphogenesis and function are essential for all vertebrate life. The heart begins as a simple contractile tube, but quickly grows and morphs into a multichambered pumping organ complete with valves, while maintaining regulation of blood flow and nutrient distribution. Though not identical, cardiac morphogenesis shares many molecular and morphological processes across vertebrate species. Quantitative data across multiple time and length scales have been gathered through decades of reductionist single variable analyses. These range from detailed molecular signaling pathways at the cellular levels to cardiac function at the tissue/organ levels. However, none of these components act in true isolation from others, and each, in turn, exhibits short- and long-range effects in both time and space. With the absence of a gene, entire signaling cascades and genetic profiles may be shifted, resulting in complex feedback mechanisms. Also taking into account local microenvironmental changes throughout development, it is apparent that a systems level approach is an essential resource to accelerate information generation concerning the functional relationships across multiple length scales (molecular data vs physiological function) and structural development. In this review, we discuss relevant in vivo and in vitro experimental approaches, compare different computational frameworks for systems modeling, and the latest information about systems modeling of cardiac development. Finally, we conclude with some important future directions for cardiac systems modeling.

Resumo Limpo

order cardiac morphogenesi function essenti vertebr life heart begin simpl contractil tube quick grow morph multichamb pump organ complet valv maintain regul blood flow nutrient distribut though ident cardiac morphogenesi share mani molecular morpholog process across vertebr speci quantit data across multipl time length scale gather decad reductionist singl variabl analys rang detail molecular signal pathway cellular level cardiac function tissueorgan level howev none compon act true isol other turn exhibit short longrang effect time space absenc gene entir signal cascad genet profil may shift result complex feedback mechan also take account local microenvironment chang throughout develop appar system level approach essenti resourc acceler inform generat concern function relationship across multipl length scale molecular data vs physiolog function structur develop review discuss relev vivo vitro experiment approach compar differ comput framework system model latest inform system model cardiac develop final conclud import futur direct cardiac system model

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