Wiley Interdiscip Rev Syst Biol Med - Engineered genetic information processing circuits.

Tópicos

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{ intervent(3218) particip(2042) group(1664) }
{ activ(1138) subject(705) human(624) }
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{ cancer(2502) breast(956) screen(824) }
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{ detect(2391) sensit(1101) algorithm(908) }

Resumo

Cells implement functions through the computation of biological information that is often mediated by genetic regulatory networks. To reprogram cells with novel capabilities, a vast set of synthetic gene circuits has recently been created. These include simple modules, such as feedback circuits, feed-forward loops, ultrasensitive networks, band-pass filters, logic gate operators and others, with each carrying a specific information processing functionality. More advanced cellular computation can also be achieved by assembling multiple simple processing modules into integrated computational cores. Further, when coupled with other modules such as sensors and actuators, integrated processing circuits enable sophisticated biological functionalities at both intra- and intercellular levels. Engineered genetic information processing circuits are transforming our ability to program cells, offering us extraordinary opportunities to explore biological mechanisms and to address real-world challenges.

Resumo Limpo

cell implement function comput biolog inform often mediat genet regulatori network reprogram cell novel capabl vast set synthet gene circuit recent creat includ simpl modul feedback circuit feedforward loop ultrasensit network bandpass filter logic gate oper other carri specif inform process function advanc cellular comput can also achiev assembl multipl simpl process modul integr comput core coupl modul sensor actuat integr process circuit enabl sophist biolog function intra intercellular level engin genet inform process circuit transform abil program cell offer us extraordinari opportun explor biolog mechan address realworld challeng

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