Wiley Interdiscip Rev Syst Biol Med - Bioimage informatics for understanding spatiotemporal dynamics of cellular processes.

Tópicos

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Resumo

The inner environment of the cell is highly dynamic and heterogeneous yet exquisitely organized. Successful completion of cellular processes within this environment depends on the right molecules or molecular complexes to function at the right place at the right time. Understanding spatiotemporal behaviors of cellular processes is therefore essential to understanding their molecular mechanisms at the systems level. These behaviors are usually visualized and recorded using imaging techniques. However, to infer from them systems-level molecular mechanisms, computational analysis and understanding of recorded image data is crucial, not only for acquiring quantitative behavior measurements but also for comprehending complex interactions among the molecules or molecular complexes involved. The technology of computational analysis and understanding of biological images is often referred to simply as bioimage informatics. This article introduces fundamentals of bioimage informatics for understanding spatiotemporal dynamics of cellular processes and reviews recent advances on this topic. Basic bioimage informatics concepts and techniques for characterizing spatiotemporal cell dynamics are introduced first. Studies on specific cellular processes such as cell migration and signal transduction are then used as examples to analyze and summarize recent advances, with the focus on transforming quantitative measurements of spatiotemporal cellular behaviors into knowledge of underlying molecular mechanisms. Despite the advances made, substantial technological challenges remain, especially in representation of spatiotemporal cellular behaviors and inference of systems-level molecular mechanisms. These challenges are briefly discussed. Overall, understanding spatiotemporal cell dynamics will provide critical insights into how specific cellular processes as well as the entire inner cellular environment are dynamically organized and regulated.

Resumo Limpo

inner environ cell high dynam heterogen yet exquisit organ success complet cellular process within environ depend right molecul molecular complex function right place right time understand spatiotempor behavior cellular process therefor essenti understand molecular mechan system level behavior usual visual record use imag techniqu howev infer systemslevel molecular mechan comput analysi understand record imag data crucial acquir quantit behavior measur also comprehend complex interact among molecul molecular complex involv technolog comput analysi understand biolog imag often refer simpli bioimag informat articl introduc fundament bioimag informat understand spatiotempor dynam cellular process review recent advanc topic basic bioimag informat concept techniqu character spatiotempor cell dynam introduc first studi specif cellular process cell migrat signal transduct use exampl analyz summar recent advanc focus transform quantit measur spatiotempor cellular behavior knowledg under molecular mechan despit advanc made substanti technolog challeng remain especi represent spatiotempor cellular behavior infer systemslevel molecular mechan challeng briefli discuss overal understand spatiotempor cell dynam will provid critic insight specif cellular process well entir inner cellular environ dynam organ regul

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