Wiley Interdiscip Rev Syst Biol Med - Accelerating cancer systems biology research through Semantic Web technology.

Tópicos

{ research(1218) medic(880) student(794) }
{ data(1714) softwar(1251) tool(1186) }
{ inform(2794) health(2639) internet(1427) }
{ care(1570) inform(1187) nurs(1089) }
{ cancer(2502) breast(956) screen(824) }
{ concept(1167) ontolog(924) domain(897) }
{ algorithm(1844) comput(1787) effici(935) }
{ research(1085) discuss(1038) issu(1018) }
{ system(1050) medic(1026) inform(1018) }
{ model(3480) simul(1196) paramet(876) }
{ control(1307) perform(991) simul(935) }
{ data(3963) clinic(1234) research(1004) }
{ patient(2837) hospit(1953) medic(668) }
{ drug(1928) target(777) effect(648) }
{ can(774) often(719) complex(702) }
{ extract(1171) text(1153) clinic(932) }
{ model(2220) cell(1177) simul(1124) }
{ search(2224) databas(1162) retriev(909) }
{ age(1611) year(1155) adult(843) }
{ sampl(1606) size(1419) use(1276) }
{ health(1844) social(1437) communiti(874) }
{ method(2212) result(1239) propos(1039) }
{ model(3404) distribut(989) bayesian(671) }
{ bind(1733) structur(1185) ligand(1036) }
{ learn(2355) train(1041) set(1003) }
{ clinic(1479) use(1117) guidelin(835) }
{ method(1557) propos(1049) approach(1037) }
{ design(1359) user(1324) use(1319) }
{ case(1353) use(1143) diagnosi(1136) }
{ visual(1396) interact(850) tool(830) }
{ compound(1573) activ(1297) structur(1058) }
{ spatial(1525) area(1432) region(1030) }
{ group(2977) signific(1463) compar(1072) }
{ intervent(3218) particip(2042) group(1664) }
{ activ(1138) subject(705) human(624) }
{ can(981) present(881) function(850) }
{ high(1669) rate(1365) level(1280) }
{ imag(1947) propos(1133) code(1026) }
{ data(1737) use(1416) pattern(1282) }
{ system(1976) rule(880) can(841) }
{ measur(2081) correl(1212) valu(896) }
{ imag(1057) registr(996) error(939) }
{ sequenc(1873) structur(1644) protein(1328) }
{ method(1219) similar(1157) match(930) }
{ featur(3375) classif(2383) classifi(1994) }
{ imag(2830) propos(1344) filter(1198) }
{ network(2748) neural(1063) input(814) }
{ imag(2675) segment(2577) method(1081) }
{ patient(2315) diseas(1263) diabet(1191) }
{ take(945) account(800) differ(722) }
{ studi(2440) review(1878) systemat(933) }
{ motion(1329) object(1292) video(1091) }
{ assess(1506) score(1403) qualiti(1306) }
{ treatment(1704) effect(941) patient(846) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ framework(1458) process(801) describ(734) }
{ problem(2511) optim(1539) algorithm(950) }
{ error(1145) method(1030) estim(1020) }
{ chang(1828) time(1643) increas(1301) }
{ general(901) number(790) one(736) }
{ method(984) reconstruct(947) comput(926) }
{ featur(1941) imag(1645) propos(1176) }
{ howev(809) still(633) remain(590) }
{ studi(1410) differ(1259) use(1210) }
{ risk(3053) factor(974) diseas(938) }
{ perform(999) metric(946) measur(919) }
{ import(1318) role(1303) understand(862) }
{ model(2341) predict(2261) use(1141) }
{ perform(1367) use(1326) method(1137) }
{ studi(1119) effect(1106) posit(819) }
{ blood(1257) pressur(1144) flow(957) }
{ record(1888) medic(1808) patient(1693) }
{ health(3367) inform(1360) care(1135) }
{ monitor(1329) mobil(1314) devic(1160) }
{ ehr(2073) health(1662) electron(1139) }
{ state(1844) use(1261) util(961) }
{ model(2656) set(1616) predict(1553) }
{ data(2317) use(1299) case(1017) }
{ medic(1828) order(1363) alert(1069) }
{ signal(2180) analysi(812) frequenc(800) }
{ cost(1906) reduc(1198) effect(832) }
{ gene(2352) biolog(1181) express(1162) }
{ data(3008) multipl(1320) sourc(1022) }
{ first(2504) two(1366) second(1323) }
{ time(1939) patient(1703) rate(768) }
{ patient(1821) servic(1111) care(1106) }
{ use(2086) technolog(871) perceiv(783) }
{ analysi(2126) use(1163) compon(1037) }
{ structur(1116) can(940) graph(676) }
{ use(976) code(926) identifi(902) }
{ use(1733) differ(960) four(931) }
{ result(1111) use(1088) new(759) }
{ implement(1333) system(1263) develop(1122) }
{ survey(1388) particip(1329) question(1065) }
{ estim(2440) model(1874) function(577) }
{ decis(3086) make(1611) patient(1517) }
{ process(1125) use(805) approach(778) }
{ activ(1452) weight(1219) physic(1104) }
{ method(1969) cluster(1462) data(1082) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

Cancer systems biology is an interdisciplinary, rapidly expanding research field in which collaborations are a critical means to advance the field. Yet the prevalent database technologies often isolate data rather than making it easily accessible. The Semantic Web has the potential to help facilitate web-based collaborative cancer research by presenting data in a manner that is self-descriptive, human and machine readable, and easily sharable. We have created a semantically linked online Digital Model Repository (DMR) for storing, managing, executing, annotating, and sharing computational cancer models. Within the DMR, distributed, multidisciplinary, and inter-organizational teams can collaborate on projects, without forfeiting intellectual property. This is achieved by the introduction of a new stakeholder to the collaboration workflow, the institutional licensing officer, part of the Technology Transfer Office. Furthermore, the DMR has achieved silver level compatibility with the National Cancer Institute's caBIG, so users can interact with the DMR not only through a web browser but also through a semantically annotated and secure web service. We also discuss the technology behind the DMR leveraging the Semantic Web, ontologies, and grid computing to provide secure inter-institutional collaboration on cancer modeling projects, online grid-based execution of shared models, and the collaboration workflow protecting researchers' intellectual property.

Resumo Limpo

cancer system biolog interdisciplinari rapid expand research field collabor critic mean advanc field yet preval databas technolog often isol data rather make easili access semant web potenti help facilit webbas collabor cancer research present data manner selfdescript human machin readabl easili sharabl creat semant link onlin digit model repositori dmr store manag execut annot share comput cancer model within dmr distribut multidisciplinari interorganiz team can collabor project without forfeit intellectu properti achiev introduct new stakehold collabor workflow institut licens offic part technolog transfer offic furthermor dmr achiev silver level compat nation cancer institut cabig user can interact dmr web browser also semant annot secur web servic also discuss technolog behind dmr leverag semant web ontolog grid comput provid secur interinstitut collabor cancer model project onlin gridbas execut share model collabor workflow protect research intellectu properti

Resumos Similares

Brief. Bioinformatics - Bioinformatics training: selecting an appropriate learning content management system--an example from the European Bioinformatics Institute. ( 0,747336087061856 )
AMIA Annu Symp Proc - Supporting the Collaborative Authoring of ICD-11 with WebProt?g?. ( 0,722959454909294 )
J Am Med Inform Assoc - Leveraging the national cyberinfrastructure for biomedical research. ( 0,717689331507722 )
J Am Med Inform Assoc - Implementation of a deidentified federated data network for population-based cohort discovery. ( 0,711543928034926 )
Methods Inf Med - MedSkills: a learning environment for evidence-based medical skills. ( 0,692861962617878 )
J Am Med Inform Assoc - Exposome informatics: considerations for the design of future biomedical research information systems. ( 0,691762792847876 )
J Am Med Inform Assoc - Direct2Experts: a pilot national network to demonstrate interoperability among research-networking platforms. ( 0,690091044224669 )
J Am Med Inform Assoc - Clinical research informatics: a conceptual perspective. ( 0,688755979566019 )
Brief. Bioinformatics - Developing an online programme in computational biology. ( 0,684774726726414 )
Brief. Bioinformatics - A toolbox for developing bioinformatics software. ( 0,683565232594055 )
J Am Med Inform Assoc - Enabling collaborative research using the Biomedical Informatics Research Network (BIRN). ( 0,680630119028443 )
Brief. Bioinformatics - Tutorial videos of bioinformatics resources: online distribution trial in Japan named TogoTV. ( 0,668139509277226 )
IEEE J Biomed Health Inform - Hardware and software realization of EDSD for acupuncture research and practice. ( 0,66614290531972 )
Health Info Libr J - Evaluating information literacy educators' practices before and after the course facilitating information literacy education: from tutor to learner-centred. ( 0,663780023296366 )
Methods Inf Med - Supporting translational research on inherited cardiomyopathies through information technology. ( 0,658800760218686 )
Brief. Bioinformatics - Buying in to bioinformatics: an introduction to commercial sequence analysis software. ( 0,657659121308536 )
Comput Methods Programs Biomed - Medical faculties educational network: multidimensional quality assessment. ( 0,654429951080153 )
Health Info Libr J - An investigation into the move towards electronic journals: a case study of NHS libraries in Kent, Surrey and Sussex. ( 0,649825131569817 )
J. Med. Internet Res. - Interactive algorithms for teaching and learning acute medicine in the network of medical faculties MEFANET. ( 0,641606687481933 )
Appl Clin Inform - Medical student appraisal: searching on smartphones. ( 0,635738836271987 )
Appl Clin Inform - The challenges of publishing on health informatics in developing countries. ( 0,632290217125415 )
Comput Methods Programs Biomed - AIBench: a rapid application development framework for translational research in biomedicine. ( 0,623887858071325 )
J Med Syst - Characteristics of successful technological interventions in mental resilience training. ( 0,623842738680731 )
Appl Clin Inform - From bed to bench: bridging from informatics practice to theory: an exploratory analysis. ( 0,621363518743222 )
AMIA Annu Symp Proc - The ontology life cycle: Integrated tools for editing, publishing, peer review, and evolution of ontologies. ( 0,621127403957335 )
J. Med. Internet Res. - Collaborative biomedicine in the age of big data: the case of cancer. ( 0,617863415306794 )
J. Med. Internet Res. - Beyond open big data: addressing unreliable research. ( 0,615719295986959 )
Brief. Bioinformatics - Bioinformatics education dissemination with an evolutionary problem solving perspective. ( 0,613812500777228 )
J Biomed Inform - NanoParticle Ontology for cancer nanotechnology research. ( 0,612482155751573 )
Brief. Bioinformatics - Bioinformatics training: a review of challenges, actions and support requirements. ( 0,612367725192949 )
Health Info Libr J - Dissemination of public health information: key tools utilised by the NECOBELAC network in Europe and Latin America. ( 0,61209100176358 )
AMIA Annu Symp Proc - Information warehouse - a comprehensive informatics platform for business, clinical, and research applications. ( 0,61175788982424 )
Brief. Bioinformatics - Bioinformatics Training Network (BTN): a community resource for bioinformatics trainers. ( 0,611316901458622 )
Health Info Libr J - The academic librarian as co-investigator on an interprofessional primary research team: a case study. ( 0,609148934518638 )
Health Info Libr J - 'Today and more than ever, I FEEL LIKE A RESEARCHER': successful online learning collaborations between librarians and a Graduate School. ( 0,608644994259551 )
J Am Med Inform Assoc - Simbios: an NIH national center for physics-based simulation of biological structures. ( 0,608621334600232 )
Comput Methods Programs Biomed - Graphical simulation environments for modelling and simulation of integrative physiology. ( 0,607222428315867 )
J Am Med Inform Assoc - CLARA: an integrated clinical research administration system. ( 0,606381976463973 )
AMIA Annu Symp Proc - The SHARPn project on secondary use of Electronic Medical Record data: progress, plans, and possibilities. ( 0,606376883876943 )
Appl Clin Inform - The health information technology workforce: estimations of demands and a framework for requirements. ( 0,606351858078488 )
Health Info Libr J - Qualified doctor and medical students' use of resources for accessing information: what is used and why? ( 0,604481156649992 )
AMIA Annu Symp Proc - The TRITON Project: Design and Implementation of an Integrative Translational Research Information Management Platform. ( 0,603694037684049 )
Brief. Bioinformatics - The semantic web in translational medicine: current applications and future directions. ( 0,602044372845978 )
BMC Med Inform Decis Mak - Text data extraction for a prospective, research-focused data mart: implementation and validation. ( 0,599612513779544 )
J Med Syst - MEDWISE: an innovative public health information system infrastructure. ( 0,598431718265104 )
Health Info Libr J - Integrating information literacy in health sciences curricula: a case study from Qu?bec. ( 0,596504190414851 )
Health Info Libr J - How the web was won ? by some. ( 0,594791763388801 )
Brief. Bioinformatics - A first course in computing with applications to biology. ( 0,594027159221185 )
J Am Med Inform Assoc - The National Center for Biomedical Ontology. ( 0,590777861661413 )
J. Med. Internet Res. - Harnessing the social web for health and wellness: issues for research and knowledge translation. ( 0,590647148555255 )
AMIA Annu Symp Proc - Gap analysis of biomedical informatics graduate education competencies. ( 0,589871877953637 )
J Am Med Inform Assoc - AMIA Board white paper: definition of biomedical informatics and specification of core competencies for graduate education in the discipline. ( 0,588715597085263 )
AMIA Annu Symp Proc - Developing an online and in-person HIT workforce training program using a team-based learning approach. ( 0,588408971158539 )
Brief. Bioinformatics - Education resources of the National Center for Biotechnology Information. ( 0,587681177617979 )
Telemed J E Health - Building the capacity to build capacity in e-health in sub-Saharan Africa: the KwaZulu-Natal experience. ( 0,586429270178261 )
Brief. Bioinformatics - The Rat Genome Database 2013--data, tools and users. ( 0,586064996908482 )
J. Med. Internet Res. - A pilot study of motivational interviewing training in a virtual world. ( 0,585575657376938 )
J. Med. Internet Res. - Massive open online courses on health and medicine: review. ( 0,58493712254926 )
Int J Comput Assist Radiol Surg - A DICOM-based 2nd generation Molecular Imaging Data Grid implementing the IHE XDS-i integration profile. ( 0,582486057924459 )
AMIA Annu Symp Proc - Using RxNorm and NDF-RT to classify medication data extracted from electronic health records: experiences from the Rochester Epidemiology Project. ( 0,58093156103971 )
Appl Clin Inform - IT Infrastructure Components for Biobanking. ( 0,580832988274472 )
Int J Med Inform - An overview of medical informatics education in China. ( 0,580675209382792 )
Brief. Bioinformatics - The NGS WikiBook: a dynamic collaborative online training effort with long-term sustainability. ( 0,580418553124444 )
Comput Methods Programs Biomed - Social Web mining and exploitation for serious applications: Technosocial Predictive Analytics and related technologies for public health, environmental and national security surveillance. ( 0,580389733409254 )
AMIA Annu Symp Proc - A student authored online medical education textbook: editing patterns and content evaluation of a medical student wiki. ( 0,58024528606766 )
Brief. Bioinformatics - Online resources of cancer data: barriers, benefits and lessons. ( 0,579851432103347 )
AMIA Annu Symp Proc - Use of standard drug vocabularies in clinical research: a case study in pediatrics. ( 0,579822217821041 )
J Am Med Inform Assoc - iDASH: integrating data for analysis, anonymization, and sharing. ( 0,579227363194463 )
Comput Methods Programs Biomed - CAIMAN: an online algorithm repository for Cancer Image Analysis. ( 0,579152436424271 )
Brief. Bioinformatics - Tools and collaborative environments for bioinformatics research. ( 0,57668637331491 )
Perspect Health Inf Manag - Gaps in the existing public health informatics training programs: a challenge to the development of a skilled global workforce. ( 0,576534374308637 )
Curr Protoc Bioinformatics - Using EMBL-EBI Services via Web Interface and Programmatically via Web Services. ( 0,576293930053772 )
BMC Med Inform Decis Mak - Clinical software development for the Web: lessons learned from the BOADICEA project. ( 0,575040358627579 )
AMIA Annu Symp Proc - A surveillance tool to support quality assurance and research in personalized medicine. ( 0,574331485646555 )
J Am Med Inform Assoc - The NIH National Center for Integrative Biomedical Informatics (NCIBI). ( 0,574101754055139 )
J Integr Bioinform - Web2.0 paves new ways for collaborative and exploratory analysis of chemical compounds in spectrometry data. ( 0,573164630432901 )
Int J Med Inform - Medical informatics: past, present, future. ( 0,572664654548181 )
Brief. Bioinformatics - Teaching the ABCs of bioinformatics: a brief introduction to the Applied Bioinformatics Course. ( 0,57257102516674 )
Health Info Libr J - Integrating evidence-based practice and information literacy skills in teaching physical and occupational therapy students. ( 0,571430285008005 )
Appl Clin Inform - Lessons learned for collaborative clinical content development. ( 0,570748034952462 )
Brief. Bioinformatics - Software applications for flux balance analysis. ( 0,569742955047093 )
AMIA Annu Symp Proc - Trends in publication of nursing informatics research. ( 0,569723019831702 )
J Med Syst - Medical students' expectations towards an implementation of a family medicine textbook as a comprehensive app in Germany. ( 0,56944424643565 )
AMIA Annu Symp Proc - ARX--A Comprehensive Tool for Anonymizing Biomedical Data. ( 0,569297669355741 )
J Am Med Inform Assoc - Bionimbus: a cloud for managing, analyzing and sharing large genomics datasets. ( 0,569104395943646 )
J Am Med Inform Assoc - R engine cell: integrating R into the i2b2 software infrastructure. ( 0,568822994818339 )
Perspect Health Inf Manag - Developing a capstone course within a health informatics program. ( 0,568226513380543 )
IEEE Trans Vis Comput Graph - A Survey of Software Frameworks for Cluster-Based Large High-Resolution Displays. ( 0,568202072694322 )
J Clin Monit Comput - Integrating Arden-Syntax-based clinical decision support with extended presentation formats into a commercial patient data management system. ( 0,567457262464443 )
Methods Inf Med - Biomedical informatics publications: a global perspective: part I: conferences. ( 0,567371351260218 )
Methods Inf Med - Training health professionals in bioinformatics. Experiences and lessons learned. ( 0,566985237356963 )
J Integr Bioinform - Bioinformatics strategies in life sciences: from data processing and data warehousing to biological knowledge extraction. ( 0,566976070795338 )
J Am Med Inform Assoc - A curricula-based comparison of biomedical and health informatics programs in the USA. ( 0,566722930514728 )
Brief. Bioinformatics - Literature mining, ontologies and information visualization for drug repurposing. ( 0,566298266451264 )
BMC Med Inform Decis Mak - Integrating the results of user research into medical device development: insights from a case study. ( 0,565917740734622 )
Perspect Health Inf Manag - Student participation and interactivity using asynchronous computer-mediated communication for resolution of an undergraduate capstone management case study. ( 0,565840168926563 )
BMC Med Inform Decis Mak - Smartphone and medical related App use among medical students and junior doctors in the United Kingdom (UK): a regional survey. ( 0,56579196962502 )
J Biomed Inform - ReVeaLD: a user-driven domain-specific interactive search platform for biomedical research. ( 0,565241621399133 )
J Biomed Inform - Associating co-authorship patterns with publications in high-impact journals. ( 0,563923636610521 )
Methods Inf Med - On IMIA's International Activities in Health and Biomedical Informatics Education. ( 0,563812273666831 )