Wiley Interdiscip Rev Syst Biol Med - Complexity and the reductionism-holism debate in systems biology.

Tópicos

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Resumo

Reductionism has largely influenced the development of science, culminating in its application to molecular biology. An increasing number of novel research findings have, however, shattered this view, showing how the molecular-reductionist approach cannot entirely handle the complexity of biological systems. Within this framework, the advent of systems biology as a new and more integrative field of research is described, along with the form which has taken on the debate of reductionism versus holism. Such an issue occupies a central position in systems biology, and nonetheless it is not always clearly delineated. This partly occurs because different dimensions (ontological, epistemological, methodological) are involved, and yet the concerned ones often remain unspecified. Besides, within systems biology different streams can be distinguished depending on the degree of commitment to embrace genuine systemic principles. Some useful insights into the future development of this discipline might be gained from the tradition of complexity and self-organization. This is especially true with regards the idea of self-reference, which incorporated into the organizational scheme is able to generate autonomy as an emergent property of the biological whole.

Resumo Limpo

reduction larg influenc develop scienc culmin applic molecular biolog increas number novel research find howev shatter view show molecularreductionist approach entir handl complex biolog system within framework advent system biolog new integr field research describ along form taken debat reduction versus holism issu occupi central posit system biolog nonetheless alway clear delin part occur differ dimens ontolog epistemolog methodolog involv yet concern one often remain unspecifi besid within system biolog differ stream can distinguish depend degre commit embrac genuin system principl use insight futur develop disciplin might gain tradit complex selforgan especi true regard idea selfrefer incorpor organiz scheme abl generat autonomi emerg properti biolog whole

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