Wiley Interdiscip Rev Syst Biol Med - Systems biology approaches to toll-like receptor signaling.

Tópicos

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Resumo

Toll-like receptor (TLR) signaling pathways constitute an evolutionarily conserved host defense system that protects against a broad range of infectious agents. Modeling of TLR signaling has been carried out at several levels. Structural models of TLRs and their adaptors, which utilize a small number of structural domains to recognize a diverse range of pathogens, provide a starting point for understanding how pathogens are recognized and signaling events initiated. Various experimental and computational techniques have been used to construct models of downstream signal transduction networks from the measurements of gene expression and chromatin structure under resting and perturbed conditions along with predicted regulatory sequence motifs. Although a complete and accurate mathematical model of all TLR signaling pathways has yet to be derived, many important modules have been identified and investigated, enhancing our understanding of innate immune responses. Extensions of these models based on emerging experimental techniques are discussed.

Resumo Limpo

tolllik receptor tlr signal pathway constitut evolutionarili conserv host defens system protect broad rang infecti agent model tlr signal carri sever level structur model tlrs adaptor util small number structur domain recogn divers rang pathogen provid start point understand pathogen recogn signal event initi various experiment comput techniqu use construct model downstream signal transduct network measur gene express chromatin structur rest perturb condit along predict regulatori sequenc motif although complet accur mathemat model tlr signal pathway yet deriv mani import modul identifi investig enhanc understand innat immun respons extens model base emerg experiment techniqu discuss

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