Wiley Interdiscip Rev Syst Biol Med - Regulatory variation: an emerging vantage point for cancer biology.

Tópicos

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{ detect(2391) sensit(1101) algorithm(908) }

Resumo

Transcriptional regulation involves complex and interdependent interactions of noncoding and coding regions of the genome with proteins that interact and modify them. Genetic variation/mutation in coding and noncoding regions of the genome can drive aberrant transcription and disease. In spite of accounting for nearly 98% of the genome comparatively little is known about the contribution of noncoding DNA elements to disease. Genome-wide association studies of complex human diseases including cancer have revealed enrichment for variants in the noncoding genome. A striking finding of recent cancer genome re-sequencing efforts has been the previously underappreciated frequency of mutations in epigenetic modifiers across a wide range of cancer types. Taken together these results point to the importance of dysregulation in transcriptional regulatory control in genesis of cancer. Powered by recent technological advancements in functional genomic profiling, exploration of normal and transformed regulatory networks will provide novel insight into the initiation and progression of cancer and open new windows to future prognostic and diagnostic tools.

Resumo Limpo

transcript regul involv complex interdepend interact noncod code region genom protein interact modifi genet variationmut code noncod region genom can drive aberr transcript diseas spite account near genom compar littl known contribut noncod dna element diseas genomewid associ studi complex human diseas includ cancer reveal enrich variant noncod genom strike find recent cancer genom resequenc effort previous underappreci frequenc mutat epigenet modifi across wide rang cancer type taken togeth result point import dysregul transcript regulatori control genesi cancer power recent technolog advanc function genom profil explor normal transform regulatori network will provid novel insight initi progress cancer open new window futur prognost diagnost tool

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