Wiley Interdiscip Rev Syst Biol Med - Computational and experimental characterization of skin mechanics: identifying current challenges and future directions.

Tópicos

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Resumo

The characterization of skin mechanics has many clinical implications and has been an active area of research for the past few decades. Biomechanical models have evolved from earlier empirical models to state-of-the-art structural models that provide linkage between tissue microstructure and macroscopic stress-strain response. To maximize the accuracy and predictive capabilities of such computational models, there is a need to reliably identify often a large number of unknown model parameters. This is critically dependent on the availability of experimental data that cover an extensive range of different deformation modes, and quantification of internal structural features, such as collagen orientation. To this end, future challenges should include the ongoing development of noninvasive instrumentation and imaging modalities for in vivo skin measurements. We highlight the important concept of tightly integrating computational models, instrumentation, and imaging modalities into a single platform to investigate skin biomechanics.

Resumo Limpo

character skin mechan mani clinic implic activ area research past decad biomechan model evolv earlier empir model stateoftheart structur model provid linkag tissu microstructur macroscop stressstrain respons maxim accuraci predict capabl comput model need reliabl identifi often larg number unknown model paramet critic depend avail experiment data cover extens rang differ deform mode quantif intern structur featur collagen orient end futur challeng includ ongo develop noninvas instrument imag modal vivo skin measur highlight import concept tight integr comput model instrument imag modal singl platform investig skin biomechan

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