Wiley Interdiscip Rev Syst Biol Med - Recent advances in prostate development and links to prostatic diseases.

Tópicos

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Resumo

The prostate is a branched ductal-acinar gland that is part of the male reproductive tract. Prostate development depends upon the integration of steroid hormone signals, paracrine interactions between the stromal and epithelial tissue layers, and the actions of cell autonomous factors. Several genes and signaling pathways are known to be required for one or more steps of prostate development including epithelial budding, duct elongation, branching morphogenesis, and/or cellular differentiation. Recent progress in the field of prostate development has included the application of genome-wide technologies including serial analysis of gene expression, expression profiling microarrays, and other large-scale approaches to identify new genes and pathways that are essential for prostate development. The aggregation of experimental results into online databases by organized multilab projects including the Genitourinary Developmental Molecular Atlas Project has also accelerated the understanding of molecular pathways that function during prostate development and identified links between prostate anatomy and molecular signaling. Rapid progress has also recently been made in understanding the nature and role of candidate stem cells in the developing and adult prostate. This has included the identification of putative prostate stem cell markers, lineage tracing, and organ reconstitution studies. However, several issues regarding their origin, precise nature, and possible role(s) in disease remain unresolved. Nevertheless, several links between prostatic developmental mechanisms and the pathogenesis of prostatic diseases including benign prostatic hyperplasia and prostate cancer have led to recent progress on targeting developmental pathways as therapeutic strategies for these diseases.

Resumo Limpo

prostat branch ductalacinar gland part male reproduct tract prostat develop depend upon integr steroid hormon signal paracrin interact stromal epitheli tissu layer action cell autonom factor sever gene signal pathway known requir one step prostat develop includ epitheli bud duct elong branch morphogenesi andor cellular differenti recent progress field prostat develop includ applic genomewid technolog includ serial analysi gene express express profil microarray largescal approach identifi new gene pathway essenti prostat develop aggreg experiment result onlin databas organ multilab project includ genitourinari development molecular atlas project also acceler understand molecular pathway function prostat develop identifi link prostat anatomi molecular signal rapid progress also recent made understand natur role candid stem cell develop adult prostat includ identif putat prostat stem cell marker lineag trace organ reconstitut studi howev sever issu regard origin precis natur possibl role diseas remain unresolv nevertheless sever link prostat development mechan pathogenesi prostat diseas includ benign prostat hyperplasia prostat cancer led recent progress target development pathway therapeut strategi diseas

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