Wiley Interdiscip Rev Syst Biol Med - Role of fibroblast growth factor signaling in vascular formation and maintenance: orchestrating signaling networks as an integrated system.

Tópicos

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Resumo

The vascular system has begun to be perceived as a dynamic organ actively controlling a wide variety of physiological processes. The structural and functional integrity of blood vessels, regulated by signaling activities finely modulating cell-cell and cell-matrix interactions, is crucial for vessel physiology, as well as basic functionality of the tissue. Throughout the process of new vessel formation, while blood vessels are actively reorganized and remodeled with migration and proliferation of vascular cells, maintenance of vascular barrier function is essentially important. These conflicting properties, i.e., dynamic cellular mobilization and maintenance of barrier integrity, are simultaneously achieved through the interaction of highly organized signaling networks governing coordinated cell-cell interplay. Recent evidence suggests that the fibroblast growth factor (FGF) system plays a regulatory role in several physiological conditions in the vascular system. In this article, we will attempt to summarize current knowledge in order to understand the mechanism of this coordination and evaluate the pivotal role of FGF signaling in integrating a diverse range of signaling events in vascular growth and maintenance.

Resumo Limpo

vascular system begun perceiv dynam organ activ control wide varieti physiolog process structur function integr blood vessel regul signal activ fine modul cellcel cellmatrix interact crucial vessel physiolog well basic function tissu throughout process new vessel format blood vessel activ reorgan remodel migrat prolifer vascular cell mainten vascular barrier function essenti import conflict properti ie dynam cellular mobil mainten barrier integr simultan achiev interact high organ signal network govern coordin cellcel interplay recent evid suggest fibroblast growth factor fgf system play regulatori role sever physiolog condit vascular system articl will attempt summar current knowledg order understand mechan coordin evalu pivot role fgf signal integr divers rang signal event vascular growth mainten

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