Wiley Interdiscip Rev Syst Biol Med - Isotope labeling experiments in metabolomics and fluxomics.

Tópicos

{ framework(1458) process(801) describ(734) }
{ model(2220) cell(1177) simul(1124) }
{ perform(1367) use(1326) method(1137) }
{ network(2748) neural(1063) input(814) }
{ studi(1410) differ(1259) use(1210) }
{ gene(2352) biolog(1181) express(1162) }
{ health(1844) social(1437) communiti(874) }
{ patient(2315) diseas(1263) diabet(1191) }
{ compound(1573) activ(1297) structur(1058) }
{ activ(1452) weight(1219) physic(1104) }
{ method(1219) similar(1157) match(930) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ data(3963) clinic(1234) research(1004) }
{ research(1085) discuss(1038) issu(1018) }
{ import(1318) role(1303) understand(862) }
{ model(3480) simul(1196) paramet(876) }
{ research(1218) medic(880) student(794) }
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{ time(1939) patient(1703) rate(768) }
{ use(976) code(926) identifi(902) }
{ result(1111) use(1088) new(759) }
{ model(3404) distribut(989) bayesian(671) }
{ can(774) often(719) complex(702) }
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{ imag(1057) registr(996) error(939) }
{ bind(1733) structur(1185) ligand(1036) }
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{ featur(1941) imag(1645) propos(1176) }
{ case(1353) use(1143) diagnosi(1136) }
{ howev(809) still(633) remain(590) }
{ risk(3053) factor(974) diseas(938) }
{ perform(999) metric(946) measur(919) }
{ system(1050) medic(1026) inform(1018) }
{ model(2341) predict(2261) use(1141) }
{ visual(1396) interact(850) tool(830) }
{ studi(1119) effect(1106) posit(819) }
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{ ehr(2073) health(1662) electron(1139) }
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{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ data(2317) use(1299) case(1017) }
{ age(1611) year(1155) adult(843) }
{ medic(1828) order(1363) alert(1069) }
{ signal(2180) analysi(812) frequenc(800) }
{ cost(1906) reduc(1198) effect(832) }
{ group(2977) signific(1463) compar(1072) }
{ data(3008) multipl(1320) sourc(1022) }
{ first(2504) two(1366) second(1323) }
{ intervent(3218) particip(2042) group(1664) }
{ activ(1138) subject(705) human(624) }
{ patient(1821) servic(1111) care(1106) }
{ use(2086) technolog(871) perceiv(783) }
{ can(981) present(881) function(850) }
{ analysi(2126) use(1163) compon(1037) }
{ structur(1116) can(940) graph(676) }
{ high(1669) rate(1365) level(1280) }
{ cancer(2502) breast(956) screen(824) }
{ use(1733) differ(960) four(931) }
{ drug(1928) target(777) effect(648) }
{ implement(1333) system(1263) develop(1122) }
{ survey(1388) particip(1329) question(1065) }
{ estim(2440) model(1874) function(577) }
{ decis(3086) make(1611) patient(1517) }
{ process(1125) use(805) approach(778) }
{ method(1969) cluster(1462) data(1082) }
{ method(2212) result(1239) propos(1039) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

Metabolomics, the study of all the small molecules in and outside a cell and fluxomics, comprising all conversion rates in a cell, are increasingly used in fundamental and applied sciences to unravel structures and activities of cellular networks and their regulation, to investigate mechanisms of diseases and toxicity, and to improve producing strains among other applications. For both fluxomics and metabolomics the application of isotopes became almost indispensable. Their use in these techniques is discussed, focusing primarily on studies applying stable isotopes and using mass spectrometry. This includes the underlying principles, experimental and computational methods used, and examples of application.

Resumo Limpo

metabolom studi small molecul outsid cell fluxom compris convers rate cell increas use fundament appli scienc unravel structur activ cellular network regul investig mechan diseas toxic improv produc strain among applic fluxom metabolom applic isotop becam almost indispens use techniqu discuss focus primarili studi appli stabl isotop use mass spectrometri includ under principl experiment comput method use exampl applic

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