Wiley Interdiscip Rev Syst Biol Med - Noncoding RNAs in gene regulation.

Tópicos

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Resumo

RNAs have been traditionally viewed as intermediates between DNA and proteins. However, there is a growing body of literature indicating that noncoding RNAs (ncRNAs) are key players for gene regulation, genome stability, and chromatin modification. In addition to the well-known small interfering RNAs and microRNAs acting in transcriptional and posttranscriptional gene silencing, recent advances in the field of transcriptome exploration have revealed novel sets of new small and large ncRNAs. Many of them appear to be conserved across mammals, and abnormal expression of several ncRNAs has been linked to a wide variety of human diseases, such as cancer. Here, we review the different classes of ncRNAs identified to date, in yeast and mammals, and we discuss the mechanisms by which they affect gene regulation.

Resumo Limpo

rnas tradit view intermedi dna protein howev grow bodi literatur indic noncod rnas ncrnas key player gene regul genom stabil chromatin modif addit wellknown small interf rnas microrna act transcript posttranscript gene silenc recent advanc field transcriptom explor reveal novel set new small larg ncrnas mani appear conserv across mammal abnorm express sever ncrnas link wide varieti human diseas cancer review differ class ncrnas identifi date yeast mammal discuss mechan affect gene regul

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