Wiley Interdiscip Rev Syst Biol Med - Cardiac function and disease: emerging role of small ubiquitin-related modifier.

Tópicos

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Resumo

Small ubiquitin-related modifiers, or SUMOs, have emerged as versatile regulators of many biological functions that do so by covalent attachment to a variety of substrates via enzymatic reactions. SUMO conjugation has also been shown to be involved in a number of human pathogenic processes. More recent advances in the SUMO field have indicated a potential role for SUMO conjugation pathway in cardiogenesis. This advanced review will describe the basic features of the SUMO conjugation pathway and will summarize the most recent studies implicating the influence of the sumoylation pathway in cardiac function under both physiological and pathological conditions. WIREs Syst Biol Med 2011 3 446-457 DOI: 10.1002/wsbm.130

Resumo Limpo

small ubiquitinrel modifi sumo emerg versatil regul mani biolog function coval attach varieti substrat via enzymat reaction sumo conjug also shown involv number human pathogen process recent advanc sumo field indic potenti role sumo conjug pathway cardiogenesi advanc review will describ basic featur sumo conjug pathway will summar recent studi implic influenc sumoyl pathway cardiac function physiolog patholog condit wire syst biol med doi wsbm

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