Wiley Interdiscip Rev Syst Biol Med - Influenza A virus infection kinetics: quantitative data and models.

Tópicos

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Resumo

Influenza A virus is an important respiratory pathogen that poses a considerable threat to public health each year during seasonal epidemics and even more so when a pandemic strain emerges. Understanding the mechanisms involved in controlling an influenza infection within a host is important and could result in new and effective treatment strategies. Kinetic models of influenza viral growth and decay can summarize data and evaluate the biological parameters governing interactions between the virus and the host. Here we discuss recent viral kinetic models for influenza. We show how these models have been used to provide insight into influenza pathogenesis and treatment, and we highlight the challenges of viral kinetic analysis, including accurate model formulation, estimation of important parameters, and the collection of detailed data sets that measure multiple variables simultaneously. WIREs Syst Biol Med 2011 3 429-445 DOI: 10.1002/wsbm.129

Resumo Limpo

influenza virus import respiratori pathogen pose consider threat public health year season epidem even pandem strain emerg understand mechan involv control influenza infect within host import result new effect treatment strategi kinet model influenza viral growth decay can summar data evalu biolog paramet govern interact virus host discuss recent viral kinet model influenza show model use provid insight influenza pathogenesi treatment highlight challeng viral kinet analysi includ accur model formul estim import paramet collect detail data set measur multipl variabl simultan wire syst biol med doi wsbm

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