Brief. Bioinformatics - Identification of aberrant pathways and network activities from high-throughput data.

Tópicos

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Resumo

Many complex diseases such as cancer are associated with changes in biological pathways and molecular networks rather than being caused by single gene alterations. A major challenge in the diagnosis and treatment of such diseases is to identify characteristic aberrancies in the biological pathways and molecular network activities and elucidate their relationship to the disease. This review presents recent progress in using high-throughput biological assays to decipher aberrant pathways and network activities. In particular, this review provides specific examples in which high-throughput data have been applied to identify relationships between diseases and aberrant pathways and network activities. The achievements in this field have been remarkable, but many challenges have yet to be addressed.

Resumo Limpo

mani complex diseas cancer associ chang biolog pathway molecular network rather caus singl gene alter major challeng diagnosi treatment diseas identifi characterist aberr biolog pathway molecular network activ elucid relationship diseas review present recent progress use highthroughput biolog assay deciph aberr pathway network activ particular review provid specif exampl highthroughput data appli identifi relationship diseas aberr pathway network activ achiev field remark mani challeng yet address

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