Brief. Bioinformatics - Evidence for short-time divergence and long-time conservation of tissue-specific expression after gene duplication.

Tópicos

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Resumo

Gene duplication is one of the main mechanisms by which genomes can acquire novel functions. It has been proposed that the retention of gene duplicates can be associated to processes of tissue expression divergence. These models predict that acquisition of divergent expression patterns should be acquired shortly after the duplication, and that larger divergence in tissue expression would be expected for paralogs, as compared to orthologs of a similar age. Many studies have shown that gene duplicates tend to have divergent expression patterns and that gene family expansions are associated with high levels of tissue specificity. However, the timeframe in which these processes occur have rarely been investigated in detail, particularly in vertebrates, and most analyses do not include direct comparisons of orthologs as a baseline for the expected levels of tissue specificity in absence of duplications. To assess the specific contribution of duplications to expression divergence, we combine here phylogenetic analyses and expression data from human and mouse. In particular, we study differences in spatial expression among human-mouse paralogs, specifically duplicated after the radiation of mammals, and compare them to pairs of orthologs in the same species. Our results show that gene duplication leads to increased levels of tissue specificity and that this tends to occur promptly after the duplication event.

Resumo Limpo

gene duplic one main mechan genom can acquir novel function propos retent gene duplic can associ process tissu express diverg model predict acquisit diverg express pattern acquir short duplic larger diverg tissu express expect paralog compar ortholog similar age mani studi shown gene duplic tend diverg express pattern gene famili expans associ high level tissu specif howev timefram process occur rare investig detail particular vertebr analys includ direct comparison ortholog baselin expect level tissu specif absenc duplic assess specif contribut duplic express diverg combin phylogenet analys express data human mous particular studi differ spatial express among humanmous paralog specif duplic radiat mammal compar pair ortholog speci result show gene duplic lead increas level tissu specif tend occur prompt duplic event

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