Brief. Bioinformatics - A unifying framework for bivalent multilocus linkage analysis of allotetraploids.

Tópicos

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Resumo

An allotetraploid has four paired sets of chromosomes derived from different diploid species, whose meiotic behavior is qualitatively different from the underlying diploids. According to a traditional view, meiotic pairing occurs only between homologous chromosomes, but new evidence indicates that homoeologous chromosomes may also pair to a lesser extent compared with homolog pairing. Here, we describe and assess a unifying analytical framework that incorporates differential chromosomal pairing into a multilocus linkage model. The preferential pairing factor is used to quantify the probability difference of pairing occurring between homologous chromosomes and homoeologous chromosomes. The unifying framework allows simultaneous estimation of the linkage, genetic interference and preferential pairing factor using commonly existing multiplex markers. We compared the unifying approach and traditional approaches assuming random chromosomal pairing by analyzing marker data collected in a full-sib family of tetraploid switchgrass, a bioenergy species whose diploid origins are undefined, but with subgenomes that are genetically well differentiated. The unifying framework provides a better tool for estimating the meiotic linkage and constructing a genetic map for allotetraploids.

Resumo Limpo

allotetraploid four pair set chromosom deriv differ diploid speci whose meiotic behavior qualit differ under diploid accord tradit view meiotic pair occur homolog chromosom new evid indic homoeolog chromosom may also pair lesser extent compar homolog pair describ assess unifi analyt framework incorpor differenti chromosom pair multilocus linkag model preferenti pair factor use quantifi probabl differ pair occur homolog chromosom homoeolog chromosom unifi framework allow simultan estim linkag genet interfer preferenti pair factor use common exist multiplex marker compar unifi approach tradit approach assum random chromosom pair analyz marker data collect fullsib famili tetraploid switchgrass bioenergi speci whose diploid origin undefin subgenom genet well differenti unifi framework provid better tool estim meiotic linkag construct genet map allotetraploid

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