Brief. Bioinformatics - Validation of gene regulatory networks: scientific and inferential.

Tópicos

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Resumo

Gene regulatory network models are a major area of study in systems and computational biology and the construction of network models is among the most important problems in these disciplines. The critical epistemological issue concerns validation. Validity can be approached from two different perspectives (i) given a hypothesized network model, its scientific validity relates to the ability to make predictions from the model that can be checked against experimental observations; and (ii) the validity of a network inference procedure must be evaluated relative to its ability to infer a network from sample points generated by the network. This article examines both perspectives in the framework of a distance function between two networks. It considers some of the obstacles to validation and provides examples of both validation paradigms.

Resumo Limpo

gene regulatori network model major area studi system comput biolog construct network model among import problem disciplin critic epistemolog issu concern valid valid can approach two differ perspect given hypothes network model scientif valid relat abil make predict model can check experiment observ ii valid network infer procedur must evalu relat abil infer network sampl point generat network articl examin perspect framework distanc function two network consid obstacl valid provid exampl valid paradigm

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