Brief. Bioinformatics - Reconciliation of metabolites and biochemical reactions for metabolic networks.

Tópicos

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Resumo

Genome-scale metabolic network reconstructions are now routinely used in the study of metabolic pathways, their evolution and design. The development of such reconstructions involves the integration of information on reactions and metabolites from the scientific literature as well as public databases and existing genome-scale metabolic models. The reconciliation of discrepancies between data from these sources generally requires significant manual curation, which constitutes a major obstacle in efforts to develop and apply genome-scale metabolic network reconstructions. In this work, we discuss some of the major difficulties encountered in the mapping and reconciliation of metabolic resources and review three recent initiatives that aim to accelerate this process, namely BKM-react, MetRxn and MNXref (presented in this article). Each of these resources provides a pre-compiled reconciliation of many of the most commonly used metabolic resources. By reducing the time required for manual curation of metabolite and reaction discrepancies, these resources aim to accelerate the development and application of high-quality genome-scale metabolic network reconstructions and models.

Resumo Limpo

genomescal metabol network reconstruct now routin use studi metabol pathway evolut design develop reconstruct involv integr inform reaction metabolit scientif literatur well public databas exist genomescal metabol model reconcili discrep data sourc general requir signific manual curat constitut major obstacl effort develop appli genomescal metabol network reconstruct work discuss major difficulti encount map reconcili metabol resourc review three recent initi aim acceler process name bkmreact metrxn mnxref present articl resourc provid precompil reconcili mani common use metabol resourc reduc time requir manual curat metabolit reaction discrep resourc aim acceler develop applic highqual genomescal metabol network reconstruct model

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