Brief. Bioinformatics - Transcription factor and microRNA co-regulatory loops: important regulatory motifs in biological processes and diseases.

Tópicos

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Resumo

Transcription factors (TFs) and microRNAs (miRNAs) can jointly regulate target gene expression in the forms of feed-forward loops (FFLs) or feedback loops (FBLs). These regulatory loops serve as important motifs in gene regulatory networks and play critical roles in multiple biological processes and different diseases. Major progress has been made in bioinformatics and experimental study for the TF and miRNA co-regulation in recent years. To further speed up its identification and functional study, it is indispensable to make a comprehensive review. In this article, we summarize the types of FFLs and FBLs and their identified methods. Then, we review the behaviors and functions for the experimentally identified loops according to biological processes and diseases. Future improvements and challenges are also discussed, which includes more powerful bioinformatics approaches and high-throughput technologies in TF and miRNA target prediction, and the integration of networks of multiple levels.

Resumo Limpo

transcript factor tfs microrna mirna can joint regul target gene express form feedforward loop ffls feedback loop fbls regulatori loop serv import motif gene regulatori network play critic role multipl biolog process differ diseas major progress made bioinformat experiment studi tf mirna coregul recent year speed identif function studi indispens make comprehens review articl summar type ffls fbls identifi method review behavior function experiment identifi loop accord biolog process diseas futur improv challeng also discuss includ power bioinformat approach highthroughput technolog tf mirna target predict integr network multipl level

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