Brief. Bioinformatics - Identifying miRNAs, targets and functions.

Tópicos

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{ drug(1928) target(777) effect(648) }
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Resumo

microRNAs (miRNAs) are small endogenous non-coding RNAs that function as the universal specificity factors in post-transcriptional gene silencing. Discovering miRNAs, identifying their targets and further inferring miRNA functions have been a critical strategy for understanding normal biological processes of miRNAs and their roles in the development of disease. In this review, we focus on computational methods of inferring miRNA functions, including miRNA functional annotation and inferring miRNA regulatory modules, by integrating heterogeneous data sources. We also briefly introduce the research in miRNA discovery and miRNA-target identification with an emphasis on the challenges to computational biology.

Resumo Limpo

microrna mirna small endogen noncod rnas function univers specif factor posttranscript gene silenc discov mirna identifi target infer mirna function critic strategi understand normal biolog process mirna role develop diseas review focus comput method infer mirna function includ mirna function annot infer mirna regulatori modul integr heterogen data sourc also briefli introduc research mirna discoveri mirnatarget identif emphasi challeng comput biolog

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