Comput Biol Chem - In silico identification of conserved microRNAs and their target transcripts from expressed sequence tags of three earthworm species.

Tópicos

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Resumo

MicroRNAs are a recently identified class of small regulatory RNAs that target more than 30% protein-coding genes. Elevating evidence shows that miRNAs play a critical role in many biological processes, including developmental timing, tissue differentiation, and response to chemical exposure. In this study, we applied a computational approach to analyze expressed sequence tags, and identified 32 miRNAs belonging to 22 miRNA families, in three earthworm species Eisenia fetida, Eisenia andrei, and Lumbricus rubellus. These newly identified earthworm miRNAs possess a difference of 2-4 nucleotides from their homologous counterparts in Caenorhabditis elegans. They also share similar features with other known animal miRNAs, for instance, the nucleotide U being dominant in both mature and pre-miRNA sequences, particularly in the first position of mature miRNA sequences at the 5' end. The newly identified earthworm miRNAs putatively regulate mRNA genes that are involved in many important biological processes and pathways related to development, growth, locomotion, and reproduction as well as response to stresses, particularly oxidative stress. Future efforts will focus on experimental validation of their presence and target mRNA genes to further elucidate their biological functions in earthworms.

Resumo Limpo

microrna recent identifi class small regulatori rnas target proteincod gene elev evid show mirna play critic role mani biolog process includ development time tissu differenti respons chemic exposur studi appli comput approach analyz express sequenc tag identifi mirna belong mirna famili three earthworm speci eisenia fetida eisenia andrei lumbricus rubellus newli identifi earthworm mirna possess differ nucleotid homolog counterpart caenorhabd elegan also share similar featur known anim mirna instanc nucleotid u domin matur premirna sequenc particular first posit matur mirna sequenc end newli identifi earthworm mirna putat regul mrna gene involv mani import biolog process pathway relat develop growth locomot reproduct well respons stress particular oxid stress futur effort will focus experiment valid presenc target mrna gene elucid biolog function earthworm

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