Comput Biol Chem - Macroscopic simulations of microtubule dynamics predict two steady-state processes governing array morphology.

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Resumo

Microtubule polymers typically function through their collective organization into a patterned array. The formation of the pattern, whether it is a relatively simple astral array or a highly complex mitotic spindle, relies on controlled microtubule nucleation and the basal dynamics parameters governing polymer growth and shortening. We have investigated the interaction between the microtubule nucleation and dynamics parameters, using macroscopic Monte Carlo simulations, to determine how these parameters contribute to the underlying microtubule array morphology (i.e. polymer density and length distribution). In addition to the well-characterized steady state achieved between free tubulin subunits and microtubule polymer, we propose that microtubule nucleation and extinction constitute a second, interdependent steady state process. Our simulation studies show that the magnitude of both nucleation and extinction additively impacts the final steady state free subunit concentration. We systematically varied individual microtubule dynamics parameters to survey the effects on array morphology and find specific sensitivity to perturbations of catastrophe frequency. Altering the cellular context for the microtubule array, we find that nucleation template number plays a defining role in shaping the microtubule length distribution and polymer density.

Resumo Limpo

microtubul polym typic function collect organ pattern array format pattern whether relat simpl astral array high complex mitot spindl reli control microtubul nucleat basal dynam paramet govern polym growth shorten investig interact microtubul nucleat dynam paramet use macroscop mont carlo simul determin paramet contribut under microtubul array morpholog ie polym densiti length distribut addit wellcharacter steadi state achiev free tubulin subunit microtubul polym propos microtubul nucleat extinct constitut second interdepend steadi state process simul studi show magnitud nucleat extinct addit impact final steadi state free subunit concentr systemat vari individu microtubul dynam paramet survey effect array morpholog find specif sensit perturb catastroph frequenc alter cellular context microtubul array find nucleat templat number play defin role shape microtubul length distribut polym densiti

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