Comput Biol Chem - On the evolution rate in mammalian mitochondrial genomes.

Tópicos

{ studi(1119) effect(1106) posit(819) }
{ spatial(1525) area(1432) region(1030) }
{ model(3480) simul(1196) paramet(876) }
{ take(945) account(800) differ(722) }
{ chang(1828) time(1643) increas(1301) }
{ use(1733) differ(960) four(931) }
{ survey(1388) particip(1329) question(1065) }
{ analysi(2126) use(1163) compon(1037) }
{ sequenc(1873) structur(1644) protein(1328) }
{ perform(1367) use(1326) method(1137) }
{ signal(2180) analysi(812) frequenc(800) }
{ result(1111) use(1088) new(759) }
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{ can(774) often(719) complex(702) }
{ imag(1947) propos(1133) code(1026) }
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{ research(1218) medic(880) student(794) }
{ gene(2352) biolog(1181) express(1162) }
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{ method(2212) result(1239) propos(1039) }
{ data(1737) use(1416) pattern(1282) }
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{ system(1976) rule(880) can(841) }
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{ ehr(2073) health(1662) electron(1139) }
{ state(1844) use(1261) util(961) }
{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ data(2317) use(1299) case(1017) }
{ age(1611) year(1155) adult(843) }
{ medic(1828) order(1363) alert(1069) }
{ cost(1906) reduc(1198) effect(832) }
{ group(2977) signific(1463) compar(1072) }
{ sampl(1606) size(1419) use(1276) }
{ data(3008) multipl(1320) sourc(1022) }
{ first(2504) two(1366) second(1323) }
{ intervent(3218) particip(2042) group(1664) }
{ activ(1138) subject(705) human(624) }
{ time(1939) patient(1703) rate(768) }
{ patient(1821) servic(1111) care(1106) }
{ use(2086) technolog(871) perceiv(783) }
{ can(981) present(881) function(850) }
{ health(1844) social(1437) communiti(874) }
{ structur(1116) can(940) graph(676) }
{ high(1669) rate(1365) level(1280) }
{ cancer(2502) breast(956) screen(824) }
{ drug(1928) target(777) effect(648) }
{ implement(1333) system(1263) develop(1122) }
{ decis(3086) make(1611) patient(1517) }
{ process(1125) use(805) approach(778) }
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{ method(1969) cluster(1462) data(1082) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

The methods of phylogenetic inference have become more and more realistic and effective since the evolution rate was taken into account. In order to study the evolution rate more comprehensively, all 13 protein coding genes in 123 mammalian mitochondrial genomes are analyzed. The evolution rates of different codon position are analyzed as well. The evolution rate is estimated by Shannon entropy. We find that the distribution of 3rd codon position doesn't follow gamma distribution and the results suggest that it follows a mixed distribution of gamma distribution and normal distribution. The relationship between different codon positions is also studied. We find that there are significant positive correlation between three codon positions. Especially between 1st codon position and 2nd codon position, there is strong linear relationship.

Resumo Limpo

method phylogenet infer becom realist effect sinc evolut rate taken account order studi evolut rate comprehens protein code gene mammalian mitochondri genom analyz evolut rate differ codon posit analyz well evolut rate estim shannon entropi find distribut rd codon posit doesnt follow gamma distribut result suggest follow mix distribut gamma distribut normal distribut relationship differ codon posit also studi find signific posit correl three codon posit especi st codon posit nd codon posit strong linear relationship

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