Comput Biol Chem - Computational determination of the orientation of a heat repeat-like domain of DNA-PKcs.

Tópicos

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Resumo

DNA dependent protein kinase catalytic subunit (DNA-PKcs) is an important regulatory protein in non-homologous end joining a process used to repair DNA double strand breaks. Medium resolution structures both from cryoEM and X-ray crystallography show the general topology of the protein and positions of helices in parts of DNA-PKcs. EM-Fold, an algorithm developed for building protein models into medium resolution density maps has been used to generate models for the heat repeat-like "Ring structure" of the molecule. We were able to computationally corroborate placement of the N-terminus of the domain that supports a previously published hypothesis. Targeted experiments are suggested to test the model.

Resumo Limpo

dna depend protein kinas catalyt subunit dnapkc import regulatori protein nonhomolog end join process use repair dna doubl strand break medium resolut structur cryoem xray crystallographi show general topolog protein posit helic part dnapkc emfold algorithm develop build protein model medium resolut densiti map use generat model heat repeatlik ring structur molecul abl comput corrobor placement nterminus domain support previous publish hypothesi target experi suggest test model

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