Comput Biol Chem - Dynamical effects of transcriptional pause-prone sites.

Tópicos

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Resumo

We study how long pause-prone sites, commonly sequence-dependent, affect transcription and RNA temporal levels in a delayed stochastic model of transcription at the single nucleotide level. We vary pause propensity, duration and the probability of premature termination of elongation at the pause site. We also study the effects of multiple pause sites. We show that pause sites can be used to fine-tune noise strength and burst size distribution of RNA levels. Varying pause rate and duration alone affects bursting but noise is not significantly affected. Noise strength can be changed by varying both parameters and, even more pronouncedly, by varying the probability of premature termination. Adding multiple pause sites amplifies the increase in noise and bursting. This regulatory mechanism of noise and bursting, being evolvable, may partially explain how different genes exhibit a wide spectrum of different behaviors. The results might assist the engineering of genes with a desired degree of noise.

Resumo Limpo

studi long pausepron site common sequencedepend affect transcript rna tempor level delay stochast model transcript singl nucleotid level vari paus propens durat probabl prematur termin elong paus site also studi effect multipl paus site show paus site can use finetun nois strength burst size distribut rna level vari paus rate durat alon affect burst nois signific affect nois strength can chang vari paramet even pronounc vari probabl prematur termin ad multipl paus site amplifi increas nois burst regulatori mechan nois burst evolv may partial explain differ gene exhibit wide spectrum differ behavior result might assist engin gene desir degre nois

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