Comput Biol Chem - Stochastic synchronization of interacting pathways in testosterone model.

Tópicos

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Resumo

We examine the possibilities of various coupling mechanisms among a group of identical stochastic oscillators via Chemical Langevin formalism where each oscillator is modeled by stochastic model of testosterone (T) releasing pathway. Our results show that the rate of synchrony among the coupled oscillators depends on various parameters namely fluctuating factor, coupling constants [symbol; see text], and interestingly on system size. The results show that synchronization is achieved much faster in classical deterministic system rather than stochastic system. Then we do large scale simulation of such coupled pathways using stochastic simulation algorithm and the detection of synchrony is measured by various order parameters such as synchronization manifolds, phase plots etc and found that the proper synchrony of the oscillators is maintained in different coupling mechanisms and support our theoretical claims. We also found that the coupling constant follows power law behavior with the systems size (V) by [symbol; see text] ~ AV(-), where =1 and A is a constant. We also examine the phase transition like behavior in all coupling mechanisms that we have considered for simulation. The behavior of the system is also investigated at thermodynamic limit; where V 8, molecular population, N 8 but N/V finite, to see the role of noise in information processing and found the destructive role in the rate of synchronization.

Resumo Limpo

examin possibl various coupl mechan among group ident stochast oscil via chemic langevin formal oscil model stochast model testosteron t releas pathway result show rate synchroni among coupl oscil depend various paramet name fluctuat factor coupl constant symbol see text interest system size result show synchron achiev much faster classic determinist system rather stochast system larg scale simul coupl pathway use stochast simul algorithm detect synchroni measur various order paramet synchron manifold phase plot etc found proper synchroni oscil maintain differ coupl mechan support theoret claim also found coupl constant follow power law behavior system size v symbol see text av constant also examin phase transit like behavior coupl mechan consid simul behavior system also investig thermodynam limit v molecular popul n nv finit see role nois inform process found destruct role rate synchron

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