Comput Biol Chem - New insights on gene regulation in archaea.

Tópicos

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{ detect(2391) sensit(1101) algorithm(908) }

Resumo

Archaea represent an important and vast domain of life. This cellular domain includes a large diversity of organisms characterized as prokaryotes with basal transcriptional machinery similar to eukarya. In this work we explore the most recent findings concerning the transcriptional regulatory organization in archaeal genomes since the perspective of the DNA-binding transcription factors (TFs), such as the high proportion of archaeal TFs homologous to bacteria, the apparent deficit of TFs, only comparable to the proportion of TFs in parasites or intracellular pathogenic bacteria, suggesting a deficit in this class of proteins. We discuss an appealing hypothesis to explain the apparent deficit of TFs in archaea, based on their characteristics, such as their small length sizes. The hypothesis suggests that a large fraction of these small-sized TFs could supply the deficit of TFs in archaea, by forming different combinations of monomers similar to that observed in eukaryotic transcriptional machinery, where a wide diversity of protein-protein interactions could act as mediators of regulatory feedback, indicating a chimera of bacterial and eukaryotic TFs' functionality. Finally, we discuss how global experiments can help to understand in a global context the role of TFs in these organisms.

Resumo Limpo

archaea repres import vast domain life cellular domain includ larg divers organ character prokaryot basal transcript machineri similar eukarya work explor recent find concern transcript regulatori organ archaeal genom sinc perspect dnabind transcript factor tfs high proport archaeal tfs homolog bacteria appar deficit tfs compar proport tfs parasit intracellular pathogen bacteria suggest deficit class protein discuss appeal hypothesi explain appar deficit tfs archaea base characterist small length size hypothesi suggest larg fraction smallsiz tfs suppli deficit tfs archaea form differ combin monom similar observ eukaryot transcript machineri wide divers proteinprotein interact act mediat regulatori feedback indic chimera bacteri eukaryot tfs function final discuss global experi can help understand global context role tfs organ

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