Comput Biol Chem - Computational analysis of 3'UTR region of CASP3 with respect to miRSNPs and SNPs in targetting miRNAs.

Tópicos

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Resumo

Apoptosis is a strictly organized course which keeps the healthy survival/death equilibrium. Disregulation in apoptosis may lead autoimmunity or cancer, but increased apoptosis can lead degenerative diseases. Studies during the last several years have identified numerous affected miRNAs in association with apoptosis, their target genes and biological functions, and possible drug interventions. Polymorphisms in miRNA genes or miRNA target sites (miRSNPs) can modify miRNA action. While polymorphisms in miRNA genes are relatively rare, SNPs in miRNA-binding sites in target genes are more frequent. Several studies have shown that SNPs in miRNA target sites enhance or weaken the interaction between miRNA and its target transcripts and are associated with cancers and other diseases. We aimed to identify miRSNPs on executioner caspase, CASP3 gene (caspase-3) and SNPs in miRNA genes targeting 3'UTR of CASP3 and assessing the impact of these miRSNPs and SNPs of miRNA genes targeting 3'UTR of CASP3 with respect to apoptosis. We identified 89 different miRNA binding sites (for 43 different miRNAs) and 16 different SNPs in binding sites of miRNA in the 3'UTR of the CASP3 gene. Also, 2 SNPs (rs372435266 and rs190144655) were found on this miRNA' genomic sequence. One of them crossmatched with a SNP in the 3'UTR of CASP3 that we found formerly. This miRNA was miR-4802-3p. Besides, miR-4802-3p targets three other apoptosis related genes, XIAP, IL1A and SOX2. This means that miR-4802-3p may also have a critical effect on apoptosis via different pathways other than caspase-3. We can therefore conclude that this is the first study proving a strong association between miR-4802-3p and apoptosis upon computational targetting analysis.

Resumo Limpo

apoptosi strict organ cours keep healthi survivaldeath equilibrium disregul apoptosi may lead autoimmun cancer increas apoptosi can lead degen diseas studi last sever year identifi numer affect mirna associ apoptosi target gene biolog function possibl drug intervent polymorph mirna gene mirna target site mirsnp can modifi mirna action polymorph mirna gene relat rare snps mirnabind site target gene frequent sever studi shown snps mirna target site enhanc weaken interact mirna target transcript associ cancer diseas aim identifi mirsnp execution caspas casp gene caspas snps mirna gene target utr casp assess impact mirsnp snps mirna gene target utr casp respect apoptosi identifi differ mirna bind site differ mirna differ snps bind site mirna utr casp gene also snps rs rs found mirna genom sequenc one crossmatch snp utr casp found former mirna mirp besid mirp target three apoptosi relat gene xiap ila sox mean mirp may also critic effect apoptosi via differ pathway caspas can therefor conclud first studi prove strong associ mirp apoptosi upon comput target analysi

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