Comput Biol Chem - The frequency of poly(G) tracts in the human genome and their use as a sensor of DNA damage.

Tópicos

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Resumo

Tandem repeats of short DNA sequences are commonly found in human DNA. These simple sequence repeats or microsatellites are highly polymorphic in the human genome. Since the anti-tumour agent cisplatin preferentially forms DNA adducts at runs of consecutive guanine nucleotides (poly(G)), the position and frequency of occurrence of poly(G) sequences in the updated human genome was investigated. There are more runs of consecutive guanines than would be expected by random chance. This especially true for poly(G) sequences longer than approximately n=9. A plot of poly(G) length against log(observed/expected) frequency produced a straight line for n>9. A similar observation was also found for poly(A) DNA sequence repeats. This data implied that the increase in observed/expected frequency is directly related to length of DNA repeat. It was proposed that long runs of consecutive guanine nucleotides could be a sensitive sensor of cellular DNA damage since a number of DNA damaging agents cause lesions at poly(G) sequences.

Resumo Limpo

tandem repeat short dna sequenc common found human dna simpl sequenc repeat microsatellit high polymorph human genom sinc antitumour agent cisplatin preferenti form dna adduct run consecut guanin nucleotid polyg posit frequenc occurr polyg sequenc updat human genom investig run consecut guanin expect random chanc especi true polyg sequenc longer approxim n plot polyg length logobservedexpect frequenc produc straight line n similar observ also found polya dna sequenc repeat data impli increas observedexpect frequenc direct relat length dna repeat propos long run consecut guanin nucleotid sensit sensor cellular dna damag sinc number dna damag agent caus lesion polyg sequenc

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