Comput Math Methods Med - Study of tumor growth under hyperthermia condition.

Tópicos

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Resumo

The new concept of keeping primary tumor under control in situ to suppress distant foci sheds light on the treatment of metastatic tumor. Hyperthermia is considered as one of the means for controlling tumor growth. To simulate the tumor growth, a continuum mathematical model has been introduced. The newest understanding of the Warburg effect on the cellular metabolism and diffusion of the nutrients in the tissue has been taken into consideration. The numerical results are compared with the in vivo experimental data by fitting the tumor cell doubling time/tumor cell growth rate under different thermal conditions. Both the tumor growth curve and corresponding average glucose concentration have been predicted. The numerical results have quantitatively illustrated the controlling effect on tumor growth under hyperthermia condition in the initial stage.

Resumo Limpo

new concept keep primari tumor control situ suppress distant foci shed light treatment metastat tumor hyperthermia consid one mean control tumor growth simul tumor growth continuum mathemat model introduc newest understand warburg effect cellular metabol diffus nutrient tissu taken consider numer result compar vivo experiment data fit tumor cell doubl timetumor cell growth rate differ thermal condit tumor growth curv correspond averag glucos concentr predict numer result quantit illustr control effect tumor growth hyperthermia condit initi stage

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