Comput Math Methods Med - Sparse reconstruction for bioluminescence tomography based on the semigreedy method.

Tópicos

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Resumo

Bioluminescence tomography (BLT) is a molecular imaging modality which can three-dimensionally resolve the molecular processes in small animals in vivo. The ill-posedness nature of BLT problem makes its reconstruction bears nonunique solution and is sensitive to noise. In this paper, we proposed a sparse BLT reconstruction algorithm based on semigreedy method. To reduce the ill-posedness and computational cost, the optimal permissible source region was automatically chosen by using an iterative search tree. The proposed method obtained fast and stable source reconstruction from the whole body and imposed constraint without using a regularization penalty term. Numerical simulations on a mouse atlas, and in vivo mouse experiments were conducted to validate the effectiveness and potential of the method.

Resumo Limpo

bioluminesc tomographi blt molecular imag modal can threedimension resolv molecular process small anim vivo illposed natur blt problem make reconstruct bear nonuniqu solut sensit nois paper propos spars blt reconstruct algorithm base semigreedi method reduc illposed comput cost optim permiss sourc region automat chosen use iter search tree propos method obtain fast stabl sourc reconstruct whole bodi impos constraint without use regular penalti term numer simul mous atlas vivo mous experi conduct valid effect potenti method

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