Comput Math Methods Med - Mathematical model of dynamic protein interactions regulating p53 protein stability for tumor suppression.

Tópicos

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Resumo

In the field of cancer biology, numerous genes or proteins form extremely complex regulatory network, which determines cancer cell fate and cancer cell survival. p53 is a major tumor suppressor that is lost in more than 50% of human cancers. It has been well known that a variety of proteins regulate its protein stability, which is essential for its tumor suppressive function. It remains elusive how we could understand and target p53 stabilization process through network analysis. In this paper we discuss the use of random walk and stationary distribution to measure the compound effect of a network of genes or proteins. This method is applied to the network of nine proteins that influence the protein stability of p53 via regulating the interaction between p53 and its regulator MDM2. Our study identifies that some proteins such as HDAC1 in the network of p53 regulators may have more profound effects on p53 stability, agreeing with the established findings on HDAC1. This work shows the importance of using mathematical analysis to dissect the complexity of biology networks in cancer.

Resumo Limpo

field cancer biolog numer gene protein form extrem complex regulatori network determin cancer cell fate cancer cell surviv p major tumor suppressor lost human cancer well known varieti protein regul protein stabil essenti tumor suppress function remain elus understand target p stabil process network analysi paper discuss use random walk stationari distribut measur compound effect network gene protein method appli network nine protein influenc protein stabil p via regul interact p regul mdm studi identifi protein hdac network p regul may profound effect p stabil agre establish find hdac work show import use mathemat analysi dissect complex biolog network cancer

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