Comput Math Methods Med - Evaluating the hemodynamical response of a cardiovascular system under support of a continuous flow left ventricular assist device via numerical modeling and simulations.

Tópicos

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Resumo

Dilated cardiomyopathy is the most common type of the heart failure which can be characterized by impaired ventricular contractility. Mechanical circulatory support devices were introduced into practice for the heart failure patients to bridge the time between the decision to transplant and the actual transplantation which is not sufficient due to the state of donor organ supply. In this study, the hemodynamic response of a cardiovascular system that includes a dilated cardiomyopathic heart under support of a newly developed continuous flow left ventricular assist device--Heart Turcica Axial--was evaluated employing computer simulations. For the evaluation, a numerical model which describes the pressure-flow rate relations of Heart Turcica Axial, a cardiovascular system model describing the healthy and pathological hemodynamics, and a baroreflex model regulating the heart rate were used. Heart Turcica Axial was operated between 8000rpm and 11,000rpm speeds with 1000rpm increments for assessing the pump performance and response of the cardiovascular system. The results also give an insight about the range of the possible operating speeds of Heart Turcica Axial in a clinical application. Based on the findings, operating speed of Heart Turcica Axial should be between 10,000rpm and 11,000rpm.

Resumo Limpo

dilat cardiomyopathi common type heart failur can character impair ventricular contractil mechan circulatori support devic introduc practic heart failur patient bridg time decis transplant actual transplant suffici due state donor organ suppli studi hemodynam respons cardiovascular system includ dilat cardiomyopath heart support newli develop continu flow left ventricular assist deviceheart turcica axialwa evalu employ comput simul evalu numer model describ pressureflow rate relat heart turcica axial cardiovascular system model describ healthi patholog hemodynam baroreflex model regul heart rate use heart turcica axial oper rpm rpm speed rpm increment assess pump perform respons cardiovascular system result also give insight rang possibl oper speed heart turcica axial clinic applic base find oper speed heart turcica axial rpm rpm

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